complex disease


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complex disease

Complex trait, polygenetic disease, polygenic disease Genetics A medical condition that arises from a intricate interaction of inherited–'nature' and environmental–'nurture' factors Examples Cancer, CAD, DM, HTN, bipolar disorder, obesity, schizophrenia. Cf Complicated disease, Mendelian genetics.

complex disease

A disease that appears to run in families but whose expression also appears to be influenced by environmental factors.
See also: disease
References in periodicals archive ?
Complicating the situation is that most complex diseases have a large number of clinical traits such as various symptoms, body metrics and family history, and that genome-wide gene expression profiling can identify tens of thousands of molecular traits associated with the disease," said Xing.
However, relatively few variants have been confirmed for complex diseases such as cancer, heart disease, and diabetes in which both susceptibility genes and environmental contributors are required for the disease to develop (Botstein and Risch 2003; Hirschhorn et al.
Complex diseases can be best addressed not by studying one specific disease, argues Wang, but by finding mechanistic commonalities underlying the pathogenesis of several diseases.
The improved resolution will help researchers interpret current genome studies aimed at finding common and rarer genetic variants associated with complex diseases.
Researchers have long known that complex diseases such as cancer and heart disease have genetic components that heavily affect their onset, progression, and response to treatment.
IBM (NYSE: IBM), the University of Utah Health Sciences Center and LineaGen Research Corporation has announced a broad collaboration to combine their respective strengths to create an unparalleled clinical genomics infrastructure designed to accelerate the molecular understanding of complex diseases and ultimately to accelerate the development of novel molecular diagnostics and targeted treatments.
Biotechnology is being applied to a range of market opportunities, from the creation of insect-resistant and herbicide-tolerant crops to the development of new pharmaceuticals that target complex diseases.
Reading Human Trials also makes a person with MS feel like a part of the international conversation that is medical research--the conversation that's ongoing, and necessary, for any successful treatment of complex diseases like MS.
Washington, Aug 18 (ANI): Earlier humans with genes that were prone to type-1 diabetes and rheumatoid arthritis may have provided them with previously unknown benefits, as a result of which, over the years, the modern man has become more prone to some complex diseases, says a new study.
Leveraging MDS Proteomics' proprietary proteomics systems and Abgenix' human antibody technologies, the companies have identified up to 150 targets for generation of human therapeutic antibody candidates intended for further development and eventual treatment for a broad range of complex diseases.
MS is one of the most complex diseases I know of," said Dr.
Recent technological advances and a growing appreciation that environmental factors contribute to most complex diseases provide unprecedented opportunities for developing new research paradigms that bring together interdisciplinary teams of Scientists to move basic environmental health sciences research into clinical and public health practice.