complement system


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com·ple·ment sys·tem

a group of more than 20 serum proteins, some of which can be serially activated and participate in a cascade resulting in cell lysis; the complement system also functions in chemotaxis, opsonization, and phagocytosis.
References in periodicals archive ?
For example, lipopolysaccharide of Mycoplasma species interacting with C1 and inducing an antibody-independent activation of the complement system via the classical pathway (Bredt et al.
These abnormalities lead to excessive activation of the complement system which can in turn lead to the development of blood clots in the filters of the kidney and in the capillaries of the heart and brain.
Annexon's mission is to develop a new class of drugs to inhibit the complement system and halt the progression of multiple neurodegenerative disorders including Alzheimer's disease, glaucoma, Parkinson's disease, spinal muscular atrophy, stroke, traumatic brain injury, multiple sclerosis, neuromyelitis optica and peripheral nervous system diseases including Guillain-Barre
It's only the old brain that has already got the complement system essentially charged up and ready to go.
Before, people thought the complement system was involved primarily in pathogenesis," said Sujan Shresta, an Associate Professor at the La Jolla Institute for Allergy and Immunology, who reviewed the paper and was not involved in the work.
These results suggest that LOX-1-CRP interaction activated the C1q-dependent classical pathway of complement system.
Normal pregnancy is characterized by systemic activation of the complement system.
The complement system is a form of "innate," or generic immunity, unlike "adaptive" immune responses, in which cellular mediators such as B and T cells learn to target specific antigens through recognition by either antibodies or cell receptors.
Studies on possible role of complement system in TPE has so far used only the classical methods like serum haemolytic component of the complement (CH50), serum C3 and C4 levels (4,5).
The adipokinome (which together with lipid moieties released, such as fatty acids and prostaglandins, constitute the secretome of fat cells) includes proteins involved in lipid metabolism, insulin sensitivity, the alternative complement system, vascular haemostasis, blood pressure regulation and angiogenesis, as well as the regulation of energy balance.
Extensively updated, the textbook includes new chapters on innate and adaptive immunity, enhanced treatment of aspects of innate immunity such as the complement system and defensins, immunotherapies, and the nature of immune response in mucosal tissues and immunological memory.

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