competitive inhibition


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Related to competitive inhibition: Uncompetitive inhibition

inhibition

 [in″hĭ-bish´un]
1. arrest or restraint of a process.
2. in psychoanalysis, the conscious or unconscious restraining of an impulse or desire. adj., adj inhib´itory.
competitive inhibition inhibition of enzyme activity by an inhibitor (a substrate analogue) that competes with the substrate for binding sites on the enzymes.
contact inhibition inhibition of cell division and cell motility in normal animal cells when in close contact with each other.
noncompetitive inhibition inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.

com·pet·i·tive in·hi·bi·tion

blocking of the action of an enzyme by a compound that binds to the free enzyme, preventing the substrate from binding and thus preventing the enzyme from acting on that substrate. The competitive inhibitor is often a substrate analogue and binds at the active site; however, this is not an absolute requirement for competitive inhibition. Saturating concentrations of substrate can remove the inhibition. Compare: isostery.

com·pet·i·tive in·hi·bi·tion

(kŏm-pet'i-tiv in'hi-bish'ŭn)
Blocking of the action of an enzyme by a compound that binds to the free enzyme, preventing the substrate from binding and thus preventing the enzyme from acting on that substrate.
Synonym(s): selective inhibition.

competitive inhibition

a form of enzyme control in which an inhibitor molecule very similar in structure to the normal SUBSTRATE of an enzyme becomes reversibly bound to the ACTIVE SITE, thus reducing the quantity of enzyme available. However, if excess substrate is present the inhibitor can be forced out by the substrate molecule which takes its place and the reaction proceeds. Compare NONCOMPETITIVE INHIBITION.

inhibition

arrest or restraint of a process.

competitive inhibition
inhibition of enzyme activity by an inhibitor (a substrate analog) that competes with the substrate for binding sites on the enzymes.
contact inhibition
inhibition of cell division and cell motility in normal animal cells when in close contact with each other.
end-product inhibition
see feedback inhibition (below).
feedback inhibition
a common way of regulating enzyme activity in which the reaction product (or in the case of a biosynthetic pathway, the product of the reaction sequence) inhibits the enzyme activity. Called also end-product inhibition.
neurological inhibition
the intermittency of transmission of nervous impulses depends on variations in the balance between excitation and inhibition, the latter being either pre- or postsynaptic.
noncompetitive inhibition
inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.
References in periodicals archive ?
Serotonin and dopamine are subject to competitive inhibition at the transporter.
The overall effect of 2-cp and 4-cp on cell growth and phenol degradation should be determined by an overall evaluation of competitive inhibition and toxicity.
These studies suggest that competitive inhibition of P sorption in the presence of LOAs is only likely to be of significance m the rhizosphere.
In addition, the presence of hydroxyl group at C-2 position of triterpenic acid in MA compared with OA could magnify its competitive inhibition on human CYP3A4 activity.
Based on this, we anticipated that there might be a possibility of separating phenol and 4-cp utilizing activated carbon adsorption so as to reduce the extent of competitive inhibition between the two compounds, and at the same time, lower the phenol liquid phase concentration, thereby decreasing the substrate inhibition effect.
Assuming competitive inhibition as the predominant mechanism of pharmacokinetic interaction related to combined exposures (Andersen et al.
A direct effect on the enzyme activity is supported by the finding that anti-TPO antibodies exert competitive inhibition with the substrate guaiacol [26].
Total antibody to HAV, on the other hand, is measured in a separate competitive inhibition (blocking) ELISA.
The Lineweaver-Burke linear transformation of the enzyme velocities versus substrate concentration showed that the ethanolic extract of crude Danshen, Danshen pill and quinidine all show competitive inhibition (Fig.
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