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competitive displacement |
Also found in: Encyclopedia | 0.04 sec. |
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competitive displacement, the tendency of one drug to displace another at nonspecific protein-binding sites (e.g., plasma albumin) when both drugs are taken at the same time. Only free drug is able to bind to its specific target proteins. An example is phenylbutazone, which has a greater affinity for binding sites on plasma proteins than warfarin. As a result, if both drugs are taken at the same time, fewer binding sites are available for warfarin, thereby increasing its free concentration in the plasma and increasing its anticoagulant action in the liver to potentially undesirable levels. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| Even though mass transport enhancements reduce the time to equilibrium, they are less efficient in the complex environment, where the competitive displacement mechanism may become rate-limiting (17,18). In the past year, adoption by the Fortune 50 has also nearly doubled to more than 25% of the largest companies in the US, competitive displacements have accelerated, channel and OEM partners are signing on rapidly, and a number of product releases have established Centrify as the most innovative vendor in the marketplace. One of these was an initial deployment of a CLM solution while the other was a competitive displacement. |
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