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compartment model |
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compartment model [kəmpärt′mənt] a mathematic representation of the body or an area of the body created to study physiologic or pharmacologic kinetic characteristics. A compartment model can simulate all of the biologic processes involved in the kinetic behavior of a drug after it has been introduced into the body, leading to a better understanding of its pharmacodynamic effects. Studies most frequently use one- or two-compartment models. In a one-compartment model the body assumes the characteristics of a homogeneous unit in which an administered drug diffuses instantaneously in the volume of body fluid. In a two-compartment model the body is represented as two distinct compartments, a central and a peripheral compartment, with two separate fluid volumes. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Raw data were analyzed as a function of time with one and two compartment models using the naive-pooled data approach (Ette & Williams 2004) and WinNonlin 5. We could have made inferences from single compartment model data (R and E) about airway responsiveness, an approach that has been taken by many investigators, including Dr. A biophysically based dermatopharmacokinetic compartment model for quantifying percutaneous penetration and absorption of topically applied agents. |
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