comparative genomic hybridization


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comparative genomic hybridization

a cytogenetic technique in which reference DNA and the DNA to be studied, as from a tumor or an embryo, are labeled with green- and red-fluorescing fluorochromes, respectively. Genetic abnormalities are detected by changes in the green-to-red ratio.
References in periodicals archive ?
Comparative genomic hybridization data for this tumor demonstrated gain of chromosome 11p, compatible with a Spitz nevus.
The amplification of C-MYC in ACC, conventional or with HGT, has not been described by FISH or comparative genomic hybridization.
or oligonucleotides: a perspective for micro array comparative genomic hybridization (array CGH).
Comparative genomic hybridization (CGH) is a molecular cytogenic technique that enables simultaneous enumeration of every chromosome, in contrast to fluorescent in situ hybridization (FISH), which at present can karyotype only a maximum of nine chromosomes, Leeanda Wilton, Ph.
This book also lacks coverage of the application of microarrays to comparative genomic hybridization and of the specific data analysis challenges associated with using DNA microarrays to measure DNA copy number as opposed to expression, as well as with the integration of both sets of data.
Researchers using NimbleGen microarrays for all applications, including comparative genomic hybridization, chromatin immunoprecipitation-on-chip, DNA methylation and gene expression can transition to Agilent arrays, effective immediately, with minimal disruption.
Previous chromosomal comparative genomic hybridization (CGH) studies of papillary thyroid carcinoma (PTC) have demonstrated a low prevalence of aberrations, with the majority of tumors showing no evidence of chromosomal instability.
This acquisition gives QIAGEN a substantial presence in two niche markets for nucleic acid purification: biobanking and DNA archiving; and comparative genomic hybridization for molecular diagnostics.
Coverage includes review of such topics as mutation scanning, cleavage, quality control, databases, and nomenclatures, followed by a section of step-by-step methods, including tag-array minisequencing, electronic hybridization, pyrosequencing, fluorescent single-stranded conformation polymorphism, denaturing high-performance liquid chromatography, array comparative genomic hybridization, and microplate array diagonal gel electrophoresis.
Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization.
BioDiscovery Nexus Copy Number software offers simple yet powerful tools for copy number variation analysis and visualization from comparative genomic hybridization arrays, single-nucleotide polymorphism arrays, as well as next-generation sequencing data.
Two new products for comparative genomic hybridization (CGH) debuted at AACR's annual meeting.
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