combined system disease

sub·a·cute com·bined de·gen·er·a·tion of the spi·nal cord

a subacute or chronic disorder of the spinal cord, such as that occurring in certain patients with vitamin B12 deficiency, characterized by a slight to moderate degree of gliosis in association with spongiform degeneration of the posterior and lateral columns.

combined system disease

a disorder of the nervous system caused by a deficiency of vitamin B12 that results in pernicious anemia and degeneration of the spinal cord and peripheral nerves, marked by increased difficulty in walking, spasticity in lower extremities, a feeling of vibration in the legs, and a loss of sense of position. Also called subacute combined degeneration of the spinal cord. See also cyanocobalamin, pernicious anemia.
Full browser ?