combined immunodeficiency

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com·bined im·mu·no·de·fi·cien·cy

immunodeficiency of both B and T lymphocytes.

com·bined im·mu·no·de·fi·cien·cy

(kŏm-bīnd' im'yū-nō-dĕ-fish'ĕn-sē)
Immunodeficiency of both the B-lymphocytes and T-lymphocytes.


a deficiency in the immune system, either that mediated by antibody or T lymphocytes, or both. See also agammaglobulinemia, hypogammaglobulinemia, feline immunodeficiency virus, bovine immunodeficiency virus.

acquired immunodeficiency
see immune deficiency disease.
cancer-associated immunodeficiency
in general, associated with cachexia and debilitation, and also related to the type of neoplasia. Tumor-related effects on the immune system include impaired function of lymphocytes, altered cytokine production and activation of suppressor cell functions.
combined immunodeficiency
common variable immunodeficiency
a term encompassing a heterogeneous group of syndromes, which may be inherited or acquired, characterized by recurring persistent infections and deficiencies of some of the immunoglobulin classes.
congenital immunodeficiency
see immune deficiency disease.
immunodeficiency disease
iatrogenic immunodeficiency
secondary immune deficiency disease.
severe combined immunodeficiency
X-linked immunodeficiency
an inherited form of severe combined immunodeficiency has been reported in dogs. Puppies fail to grow and die from overwhelming infections at an early age.
References in periodicals archive ?
1 Hemophagocytic lymphohistiocytosis 11 10/1 4-96 2 X-linked agammaglobulinemia 7 7/0 27-216 3 Chronic granulomatous disease 4 3/1 7-60 4 Severe combined immunodeficiency 4 4/0 4-48 5 Common variable immunodeficiency 3 2/1 84-120 6 Chediak-Higashi syndrome 3 1/2 26-86 7 Hypogammaglobulinemia 2 1/1 96-108 8 IgG subclass deficiency 2 0/2 84-114 9 Hyper-IgM syndrome 2 2/0 17-59 10 Autoimmune lymphoproliferative 1 0/1 15 syndrome 11 B cell expansion with NF-[kappa]B 1 1/0 18 and T cell anergy 12 Hyper-IgE syndrome 1 1/0 42 13 Interleukin 12 receptor [beta]1 1 1/0 156 Total defect 42 33/9 4-216 * PID, primary immunodeficiency Table 2.
Development of population-based newborn screening for severe combined immunodeficiency.
Severe Combined Immunodeficiency (SCID) group includes primary immunodeficiencies that lead to severe life threatening infections and are usually fatal in infancy.
Although the start-up cost for automating the test was high--requiring installation of $500,000 worth of equipment-and running the test will cost Wisconsin about another $400,000 each year, the anticipated saving in medical costs for treating a single infant who develops complications from severe combined immunodeficiency (SCID) is about $2 million, Dr.
29, 2005, during testing of a stool sample from a 7-month-old infant with severe combined immunodeficiency disease.
Yesterday, the couple, from Grangemouth, Stirlingshire, appealed to potential donors to come forward to help their little girl Teigan's condition, severe combined immunodeficiency, affects only one in 100,000 people.
In the cases of the children who developed cancer, French scientists were using a virus known as a retrovirus to put healthy genes into 11 children suffering from severe combined immunodeficiency syndrome.
The Hokkaido University Hospital will conduct research into adenosine deaminase deficiency, while Tohoku University Hospital will engage in studies of X-Linked Severe Combined Immunodeficiency, the officials said.
Now, gene therapy at London's Great Ormond Street Hospital for Children appears to have delivered a cure - the first time British doctors have successfully corrected the gene defect that causes Severe Combined Immunodeficiency Disorder (SCID).
Three products are currently marketed which utilize Enzon's technology: PEG-INTRON marketed by Schering-Plough for hepatitis C, ONCASPAR(R) for Acute Lymphoblastic Leukemia (ALL), and ADAGEN(R) a treatment for a form of Severe Combined Immunodeficiency Disease (SCID), commonly known as the "Bubble Boy Disease.
A study published in the April 28, 2000, issue of "Science" describes research by French doctors who gave two infants a normal copy of a defective gene that is the leading cause of severe combined immunodeficiency disease (SCID).

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