combinatorial library

combinatorial library

A collection of chemical compounds, so designated because it has so many structures and variants that special methods are needed to catalogue, store and retrieve individual units—as in a real library.

Combinatorial libraries can exist as molecules free in solution linked to a solid substrate (e.g., a bead), or arranged on the surface of a microorganism. They are created either by split synthesis or parallel synthesis.

combinatorial library

in immunology, the ligation of cDNAs of light and heavy chains of immunoglobulins, each in a separate bacteriophage vector.
References in periodicals archive ?
During the past decades, Creative Biomart has always been devoting to innovate product quality and production techniques and many achievements have been gained, for example, its BacTECTM and FoldEZTM technological platform to express tricky proteins, its GenePowerTM technology to create genetic variants for research purpose, its GenePowerTM Combinatorial Library Lipid-based Protein immobilization technology to immobilize native membrane proteins in the form of proteoliposomes, generated directly from cells or tissue and so many others.
The license includes approximately 10 issued patents and several patent applications as well as use of a combinatorial library of 114 polymers with a range of physical properties.
High throughput methods are the companion techniques that use a sequential process to evaluate or measure the properties of samples in the combinatorial library.
Our goal was to exploit the combinatorial library as a valuable tool for the discovery of small molecules as diagnostic agents that bind tightly with disease-specific antibodies.
The combinatorial chemistry asset, which Ligand obtained in the acquisition of Pharmacopeia in December 2008, comprises an encoded combinatorial library collection (ECLiPS) and an ultra-high throughput screening platform.
CombiFlexX has the power to identify promising drug candidates by predicting the way compounds in a combinatorial library dock into a desired target, and then gauge the effectiveness of that drug-target interaction.
This patent is the first to issue in the name of Cadus Pharmaceutical Corporation and the first relating to its Self-Selecting Combinatorial Library technology.
today announced the initiation of a joint research and license alliance to screen targets using Trevena's novel biological platform against Ligand's combinatorial library of compounds, to identify active compounds with potential for development as novel G-protein coupled receptor (GPCR) therapeutics.
This expertise is now being leveraged to develop drugs outside of the cardiovascular arena using our proficiency in medicinal chemistry and protease inhibition, combinatorial library design and synthesis.
High Throughput Screening (HTS): HTS is the rapid assessment of sample activity of samples from a combinatorial library or other compound libraries by running assays in parallel in 96 well or 384 microplates.
Eugene Vaisberg, President & CEO of ChemBridge Corporation and Chairman & CEO of ChemBridge Research Laboratories (CRL) said: "I am very pleased that our flagship lead discovery tool PHARMACore(TM) combinatorial library, which has gained within the first year broad recognition by major US and European pharmaceutical and biotech companies (such as Roche, Pharmacia, Tularik, Astra-Zeneca and Bristol Myers Squibb) has now successfully entered the Japanese market.
0 lets the scientist combine the protein flexibility features of FlexE with either the pharmacophore constraints of FlexX-Pharm or the fast combinatorial library docking of FlexXC.

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