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The branch of chemistry in which a few basic molecules are combined in various ways to yield a large number of different products; often undertaken in pharmaceutical research.
combinatorial chemistryThe science of creating chemical diversity, a chemistry-based platform for systematically assembling known chemical entities—molecular building blocks—in as many different combinations as possible, generating millions of new screenable compounds for rapid drug discovery. The strategy is to assemble every possible combination of a given set of chemical building blocks while simulataneously recording which ones have been used and in what order, then assay the resulting molecules at once and refer to the record to determine the identity of any that look promising.
Drugs developed by traditional synthetic chemistry require an average of 12 years to identify, while combinatorial compounds of potential interest may be identified within a month; most compounds thusfar created are peptides and oligonucleotides. In the pharmaceutical industry, combinatorial “libraries” of millions of compounds may be produced by smaller biotechnology companies, which may be purchased in part or their entirety by larger companies seeking leads for newer therapeutic agents.
Phases, CC research
Synthesis, distribution, inventorying, screening.
The manufacturing of molecules having specific sizes, shapes, or functional characteristics using computer-aided algorithms or design rules.
See also: chemistry