combinatorial chemistry


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combinatorial chemistry

The branch of chemistry in which a few basic molecules are combined in various ways to yield a large number of different products; often undertaken in pharmaceutical research.

combinatorial chemistry

The science of creating chemical diversity, a chemistry-based platform for systematically assembling known chemical entities—molecular building blocks—in as many different combinations as possible, generating millions of new screenable compounds for rapid drug discovery. The strategy is to assemble every possible combination of a given set of chemical building blocks while simulataneously recording which ones have been used and in what order, then assay the resulting molecules at once and refer to the record to determine the identity of any that look promising.

Drugs developed by traditional synthetic chemistry require an average of 12 years to identify, while combinatorial compounds of potential interest may be identified within a month; most compounds thusfar created are peptides and oligonucleotides. In the pharmaceutical industry, combinatorial “libraries” of millions of compounds may be produced by smaller biotechnology companies, which may be purchased in part or their entirety by larger companies seeking leads for newer therapeutic agents.
 
Phases, CC research
Synthesis, distribution, inventorying, screening.

combinatorial chemistry

The manufacturing of molecules having specific sizes, shapes, or functional characteristics using computer-aided algorithms or design rules.
See also: chemistry
References in periodicals archive ?
The technology of combinatorial chemistry is developing an engineering thrust.
As a result, combined demand for combinatorial chemistry instruments will grow at nine percent annually.
The SINTEF/UOP Combinatorial Chemistry Alliance was established in 1997.
Peoria, IL 61604) have used combinatorial chemistry with highly pressurized supercritical fluids to optimize extraction processes, to evaluate the efficiency of enzymes and to enrich nutraceuticals and other compounds sourced from plant-derived oils.
In addition to its widespread use in the pharmaceutical industry, combinatorial chemistry has recently been adopted by researchers in several other industries including agriculture and materials, where the growth potential is substantial.
Combinatorial chemistry uses advanced computer modelling as well as robotics to identify promising molecules and systematically react them in thousands of different combinations at once.
Mimotopes is a worldwide research service and supply company offering combinatorial chemistry and custom manufacture of chemical compounds, peptides, and related materials and kits.
At the same time, the techniques of combinatorial chemistry have radically changed the way drug companies look for new drug candidates.
a total solution oriented instrumental company, develops and manufactures instruments for combinatorial chemistry applications.
The collaboration will allow the ICCB and researchers at the University use of Pharmacopeia's unique approach to small molecule combinatorial chemistry, known as ECLiPS(TM).
Prior roles at Pfizer include, among others, being the chemistry team leader for the project that discovered sildenafil (Viagra(TM)), being Section Head of Pfizer's first combinatorial chemistry group, and managing several other research groups within Pfizer.

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