With the increased use of screening mammography and needle core biopsy sampling, columnar cell
change has become a frequent finding in needle core biopsies performed for calcifications.
In view of these findings, it has been suggested that the columnar cell
variant should not necessarily be treated as an aggressive subtype of PTC; instead, treatment should be based on clinical staging, with a focus on tumor encapsulation and invasion beyond the confines of the thyroid gland.
One study performed by Simpson et al (17) examined a variety of columnar cell
lesions from 18 patients by means of classic comparative genomic hybridization analysis.
Of the 6 histologic parameters, the presence of dirty necrosis, seen in 5 (100%) of 5 cases of CRCa and 2 (18%) of 11 cases of PCa, and the presence of columnar cells
with basal nuclei, seen in 5 (100%) of 5 cases of CRCa and 1 (9%) of 11 cases of PCa, were the most useful parameters.
For epithelial cells of the mantle in Mercenaria mercenaria of Veneridae, the outer epidermis is mostly composed of cuboidal cells, whereas mostly columnar cells
are present in the inner epidermis (Neff 1972a, Neff 1972b).
There are columnar cells
and numerous mucus-secreting goblet cells (Fig.
Prior prostate core specimens include neoplastic glands that are composed of mostly columnar cells
with compact eosinophilic cytoplasms, large nuclei and prominent nucleoli (hematoxylin and eosin stain [H&E] x40).
It is composed of 3 types of cells: (1) the basal cells, which are cylindrical to flat and in contact with the underlying fibroconnective tissue or lamina propria--the basal cell layer is thought to harbor urothelial stem cells; (2) the intermediate cells, which are cuboidal to columnar cells
, overlie the basal cells, and usually have the same orientation toward the bladder lumen; and (3) the umbrella cells, which are larger flat eosinophilic cells, with ample pink cytoplasm and variable nuclear reactive/degenerative atypia such as binucleation, smudging, and nucleoli.
The epithelium of buccal cavity consists of 3 cell types, the tall granulated columnar cells
bearing microvilli; which appear as a "brush border" under the light microscope, the nongranulated cells, and the mucus cells having a "goblet" appearance; which are widely scattered in the epithelium (Fig.
With incomplete IM, a periodic acid-Schiff/Alcian blue stain highlights the acid mucin of goblet cells blue, whereas the alternating areas of neutral gastric foveolar-type mucin appear as magenta-colored "caps" within the columnar cells
These mixed tall and columnar cells
feature small, dark nuclei and uniformly condensed chromatin near the center of the cell.
Most of surface epithelium, particularly at the basal part of the tentacle, is covered by columnar cells
bearing a brush border (Figs.