colony-stimulating factors


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colony-stimulating factors (CSF),

a group of glycoprotein growth factors regulating differentiation of myeloid cells. These substances act in either paracrine or autocrine fashion on marrow cells; appear to act synergistically in complex and poorly understood ways; each seems to have the ability to exert action on several lines of progenitor cells, and to influence end cell function.

col·o·ny-stim·u·lat·ing fac·tors

(CSF) (kol'ŏ-nē-stim'yū-lāt-ing fak'tŏrz)
A group of glycoprotein growth factors regulating differentiation in myeloid cell lines.

colony

a discrete group of organisms, as a single cluster of bacteria in a culture that was produced from a single starting bacterium.

colony-forming units
colonies of pluripotent stem cells located and quantified in the spleen. Colonies grown in vitro interact with erythropoietin to give rise to morphologically identifiable erythroid cells.
colony-stimulating factors
cytokines produced by lymphocytes and mononuclear phagocytes which stimulate the growth and differentiation of hematopoietic cells. Includes granulocyte-macrophage colony-stimulating factor, monocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor.
References in periodicals archive ?
Granulocyte colony-stimulating factor (G-CSF) is a naturally occurring hormone that is produced by the body to stimulate the bone marrow to produce neutrophils, a type of white blood cell that helps the immune system fight infection.
19, 2014 /PRNewswire/ -- Decision Resources Group finds that sales of biosimilar versions of the granulocyte colony-stimulating factors (G-CSFs) filgrastim, which is currently pending FDA approval, and pegfilgrastim could reach $1.
An analysis of 14 randomized clinical trials demonstrate that granulocyte colony-stimulating factors (G-CSFs) administered in the first and subsequent cycles of chemotherapy reduce the incidence of febrile neutropenia (low white blood cell count with fever) and infection-related mortality in cancer patients.