Recent research from Belgium using an animal model has identified that butyrate directly influences colonocyte
oxygen consumption through the beta-oxidation pathway leading to a symbiotic effect in normal gut by maintaining obligate anaerobes rather than facultative anaerobes such as pathogenic Escherichia and Salmonella by limiting the availability of oxygen in the gut, Additionally; gut nitrate is essential for facultative anaerobes, which is formed via nitric oxide synthase 2.
This enzyme, present in its own colonocyte
, may be responsible for the increase of nitrite levels in the mild colitis group.
This lack of colonocyte
nutrition leads to an inflammatory reaction.
The place of short-chain fatty acids in colonocyte
metabolism in health and ulcerative colitis: the impaired colonocyte
DHA alters colonocyte
mitochondrial membrane composition and function to create a pathway for butyrate and other metabolites to induce apoptosis.
Dietary flavonoids protect human colonocyte
DNA from oxidative attack in vitro.
tests also share the same advantage as FOBTs with respect to being non-invasive, relatively inexpensive, and relatively easy to perform.
Thus prevention is key, because it is hard to rebuild the colonocyte
population once ulcerative colitis has begun.
Dobson, "Dietary flavonoids protect human colonocyte
DNA from oxidative attack in vitro," European Journal of Nutrition, vol.
difficile's toxin A from activating nuclear factor-[kappa]B (NF-[kappa]B), which is how toxin A causes colonocyte
He has hypothesized that the short chain fatty acids produced by probiotic microorganisms may improve entero- and colonocyte
function, thereby reducing the incidence of diarrhea.