Thus prevention is key, because it is hard to rebuild the colonocyte
population once ulcerative colitis has begun.
difficile's toxin A from activating nuclear factor-[kappa]B (NF-[kappa]B), which is how toxin A causes colonocyte
According to an article published in The American Journal of Clinical Nutrition, hydrogen sulfide is toxic to colonocyte
(colonic mucosal), which is implicated in UC.
This lack of colonocyte
nutrition leads to an inflammatory reaction.
DHA alters colonocyte
mitochondrial membrane composition and function to create a pathway for butyrate and other metabolites to induce apoptosis.
tests also share the same advantage as FOBTs with respect to being non-invasive, relatively inexpensive, and relatively easy to perform.
He has hypothesized that the short chain fatty acids produced by probiotic microorganisms may improve entero- and colonocyte
function, thereby reducing the incidence of diarrhea.
Davies' work to date involves colonocytes
analyzed within 2 hours of defecation.
This is associated with the induction of apoptosis in colonocytes
and attenuation of proliferative responses, as well as a reduction in colonic concentrations of carcinogenic enzymes.
Acetic, propionic and butyric acids are taken up by the colonic mucosa, though butyric acid appears to be the preferred energy source for the colonocytes
Many intracellular processes depend on the oxidation of n-butyrate in membrane lipid biosynthesis, ion absorption, mucin synthesis and detoxification processes in colonocytes
, and diminished n-butyrate metabolism is likely to compromise the epithelial cell barrier (Deplancke et al.
Quantitation of DNA from exfoliated colonocytes
isolated from human stool surface as a novel noninvasive screening test for colorectal cancer.