collecting duct carcinoma

collecting duct carcinoma

A rare (1% of kidney cancers) tumour that arises in the renal collecting duct epithelium, often in middle-aged males (male:female, 2–4:1).

DiffDx
Papillary lesion (e.g., transitional cell carcinoma), metastatic carcinoma, renal medullary carcinoma.

Prognosis
Often advanced when diagnosed, some are very aggressive with half metastasising to regional nodes.
References in periodicals archive ?
Collecting duct carcinoma of the kidney: CT and pathologic correlation.
Originally, TCC was believed to be a subtype of collecting duct carcinoma that was first described by Masson, who coined the moniker "Bellinian epithelioma" or "carcinoma of the collecting ducts" because he thought it originated from collecting ducts of Bellini (1).
34,35) However, TC-RCC is currently considered as a distinct morphological entity that is separate from the biologically aggressive collecting duct carcinoma but is closely related to papillary RCC.
While urothelial carcinoma (UC) of the upper urinary tract, collecting duct carcinoma (CDC), and renal medullary carcinoma (RMC) are usually centered in the renal medullary/sinus region, clear cell type renal cell carcinoma (clear cell type RCC) and papillary RCC (commonly, type 2 papillary RCC), may extend to involve the renal sinus fat.
The current classification of renal cell carcinoma includes four main types: conventional (clear cell), papillary, chromophobe, and collecting duct carcinoma, as well as unclassified renal cell carcinoma.
An immunohistochemical panel was applied to confirm the diagnosis and rule out tumours with similar morphology, such as collecting duct carcinoma and mixed epithelial stromal tumour (MEST).
Similarly, high-molecular-weight cytokeratin is expressed in the collecting duct and urothelium; therefore, it is expected to be expressed in collecting duct carcinoma and urothelial carcinoma.
Bellini duct or collecting duct carcinoma (CDC) is a rare aggressive variant of renal cell carcinoma associated with poor prognosis, which warrants early recognition and management.
The relationship of these tumors to collecting duct carcinoma and papillary RCC remains controversial.
Collecting duct carcinoma of the kidney: are imaging findings suggestive of the diagnosis?
Collecting duct carcinoma is the rarest type of RCC (<1%).
Another diagnostic advantage of PAX-2 is that it stains all metastatic collecting duct carcinoma in the current study, as well as their primary tumors, which confirms a finding that was observed previously.

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