collecting duct carcinoma

collecting duct carcinoma

A rare (1% of kidney cancers) tumour that arises in the renal collecting duct epithelium, often in middle-aged males (male:female, 2–4:1).

DiffDx
Papillary lesion (e.g., transitional cell carcinoma), metastatic carcinoma, renal medullary carcinoma.

Prognosis
Often advanced when diagnosed, some are very aggressive with half metastasising to regional nodes.
References in periodicals archive ?
One case each of collecting duct carcinoma and RCC with oncocytic features was encountered.
3) Transitional cell carcinoma, renal lymphoma, and collecting duct carcinoma may present with a central location and an infiltrative pattern.
As previously mentioned, from a molecular standpoint, type 2 PRCC represents a heterogeneous group of molecularly distinct tumors and is currently considered to be a diagnosis of exclusion; other RCC entities with papillary architecture (ie, hereditary leiomyomatosis and RCC [HLRCC]-associated RCC, collecting duct carcinoma [CDC], among others) should be ruled out before rendering a diagnosis of type 2 PRCC.
It is challenging to differentiate MTSCC from other renal cell carcinoma subtypes that exhibit comparable morphologic features, but have a less favorable prognosis--namely papillary renal cell carcinoma, collecting duct carcinoma, metanephric adenoma or sarcomatoid carcinomas.
34,35) However, TC-RCC is currently considered as a distinct morphological entity that is separate from the biologically aggressive collecting duct carcinoma but is closely related to papillary RCC.
LELCs are distinguished from collecting duct carcinoma by the absence of desmoplasia and marked cytological atypia.
Recent advancements in the understanding of the genetics of RCC have led to a new pathological classification of five different subtypes of RCCs: clear cell, papillary, chromophobe, collecting duct carcinoma (Bellini Duct tumor), and renal carcinoma unclassified (renal medullary carcinoma).
Collecting duct carcinoma (CDC) is a rare, aggressive renal tumor with high-grade cytomorphology and nuclear features, which in some cases may enter the differential diagnosis of t-RCC.
An immunohistochemical panel was applied to confirm the diagnosis and rule out tumours with similar morphology, such as collecting duct carcinoma and mixed epithelial stromal tumour (MEST).
1-3) Other uncommon and rare renal epithelial neoplasms include clear cell papillary renal cell carcinoma (CPRCC), mucinous tubular and spindle cell carcinoma, renal medullary carcinoma, collecting duct carcinoma (CDC), tubulocystic renal cell carcinoma, and Xp11 translocation renal cell carcinoma (TRCC).

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