collapsin

collapsin

(kō-laps'in),
A secreted protein found in bird and rat embryos that collapses the growth cone of axons originating in spinal ganglia. Thought to pattern sensory projections from the ganglia by selectively repelling certain axons so that they terminate dorsally.
Synonym(s): semaphorin III
References in periodicals archive ?
Collapsin response mediator proteins (CRMPs) are a new class of microtubule-associated protein (MAP) that selectively interacts with assembled microtubules via a taxol-sensitive binding interaction.
Collapsin response mediator protein-2 accelerates axon regeneration of nerve-injured motor neurons of rat.
3 Target Protects As easy user as possible effectively Design Requirement Parts Characteristic Battery Part Collapsin Charging Travel Customer Requirement Counts Steps Time Range Capability Functional Requirements Collapsible (a) (a) Easy to Use Capable of Long Travel (a) Range Capable of Decelerating and Braking Capable of Pirouetting Ergonomics Requirements Ergonomics High Mobility (a) (a) Comfort Self-Maneuverability (a) Rain Shelter (a) Interface Requirements Convenient Maintenance (a) (b) Design Safety (c) (b) Large Battery Capacity (a) (a) Importance Absolute Weighting 54 43 50 87 Relative Weighting (%) 8.
According to the company Web site, lacosamide has a novel dual method of action, selectively enhancing slow inactivation of voltage-gated sodium channels, and modulating collapsin response mediator protein 2 (CRMP-2).
Collapsin, semaforin, tenassin, konroditin sulfat ve keratan sulfat proteoglikanlarinin yaralanma sahasinda aksonal rejenerasyonu inhibe ettiklerinden suphelenilmektedir (11).
Preclinical studies also suggest that Vimpat([R]) binds to the collapsin response mediator protein-2 (CRMP-2), an important target that affects the way that nerves differentiate and grow.
New evidence shows that while collapsin repulses some tips, called growth cones, it attracts others, says Tessier-Lavigne.
Preclinical studies also suggest that Vimpat(R) binds to the collapsin response mediator protein-2 (CRMP-2), an important target that affects the way that nerves differentiate and grow.
Unlike other drugs that treat epilepsy and diabetic neuropathic pain, lacosamide selectively enhances slow inactivation of voltage-gated sodium channels, and modulates collapsin response mediator protein 2 (CRMP-2) -- Lacosamide was shown to have potent and broad neuroprotective effects in-vitro and in animal models, which may positively influence the pathogenesis of epilepsy with long-term use -- Combinations of lacosamide with other antiepileptic drugs were associated with potential synergistic anticonvulsant effects -- Lacosamide was highly-active in multiple pre-clinical models of different seizure types and attenuation of seizure spread.
Axons--the long extensions formed by growing brain cells--display neuropilin-1, which reacts to proteins called semaphorins or collapsins, which serve as axonal stop signs.
Tessier-Lavigne explains that repellent molecules, such as a group known as collapsins or semaphorins, send a chemical message to axons, saying, "Don't come this way.