collagenous micronodule

collagenous micronodule

A microscopic focus of paucicellular eosinophilic fibrillar stroma which impinges on glandular lumina in prostate cancer. While some authors regard collagenous micronodules as specific, they are a rare finding in prostate cancer and lack prognostic significance.
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Additionally, the presence of glomerulation, collagenous micronodules (mucinous fibroplasia), circumferential perineural invasion, and glands in fat have been shown to be unequivocal histologic findings for the diagnosis of prostatic carcinoma.
Prostate Adenocarcinoma With Collagenous Micronodules.
Gleason Grading of Unusual Subtypes and Patterns of Prostate Cancer Histologic Type or Pattern Gleason Grade Foamy gland pattern Graded by underlyingarchitecture Pseudohyperplastic 3 Atrophic 3 Large duct carcinoma 4;with evidence of necrosis, 5 Signet ring cell carcinoma 5 Small cell carcinoma Not graded Adenosquamous and squamous Not graded carcinoma Sarcomatoid carcinoma Not graded Glomeruloid pattern 3 or 4 Collagenous micronodules Usually 3, graded by underlying architecture (subtract collagenous micronodules from analysis) Mucinous (colloid) carcinoma 3 or 4, graded by underlying architecture
The incidence of the following features was analyzed in cancerous and noncancerous epithelium in each case: prominent nucleoli, multiple nucleoli, nucleolar margination, intraluminal crystalloids, intraluminal basophilic mucin, intraluminal amorphous eosinophilic material, collagenous micronodules, glomerulations, retraction clefts, perineural invasion, and glands infiltrating adipose tissue.
15) Collagenous micronodules and glomerulations were identified as described in the literature.
Like glomerulations, collagenous micronodules were not observed in any of the benign biopsies, being found in 3 (2%) cases of cancer (Figure 6).
Collagenous micronodules are another relatively recently described histologic observation in prostate cancer.
However, as noted by Baisden et al, (13) collagenous micronodules are very rarely the key feature in the diagnosis of limited cancer.