varies in degree, with some lesions being extensively hyalinized.
There was extensive marrow fibrosis with focal collagenization
[4+] (Figures 3, 4).
Histological examination revealed absence of any atypia or increased mitotic activity excluded malignancy, while the absence of osteoid formation and the prominent collagenization
, helped distinguish the lesion from non-ossifying fibroma or odontogenic fibroma.
Histologically, they demonstrate a fibrous stroma with varying degrees of collagenization
and irregular blood vessels, which become smaller and more abundant at the periphery of the tumor (figure, A).
Connective tissue and parenchymal cells cause remodelling that leads to collagenization
and wound shrinkage.
Immunostaining for collagen types I, III and VI in our rats revealed diabetes-induced increase in renal collagenization
The microporosity of the polyurethane graft encourages cellular ingrowth, leading to collagenization
of the synthetic structure.
of the airway-centered nodules progresses from the inside out, resulting in paucicellular fibrotic nodules with absent or scant Langerhans cells limited to the periphery of the lesions.
The hypocellular BM showed marked reticulin fibrosis and collagenization
(Figure 2 a, b, e, f).
Goldsmith et al described solitary fibrous tumors cytologically as bland spindle-shaped cells with varying cellularity, variable dense collagenization
, and prominent vascularity.
Disruption of tissue integrity initiates a complex series of events (namely wound repair), consisting of a predictable set of responses whatever the initiating agent (surgical excisions or incisions, physical or chemical damage, trauma or infection) or the depth of injury; it involves several steps, including hemostasis, acute inflammation, granulation tissue formation, matrix formation, remodelling of connective tissue, collagenization
and acquisition of wound strength (Schaffer and Nanney, 1996).
7-10) In one study, (8) on sequential biopsies, collagenization
became somewhat more prominent, but a densely cellular follicular organization was nonetheless preserved.