Granulation tissue in the papain-urea treated group had more macrophages, with less collagenation and fibroblasts (Figure 5).
This was confirmed histopathologically where there was abundant collagenation in the fusidate-treated group.
Thus, we proposed that PR might effectively exert resistance to collagenation by mediating this signaling pathway.
Counteractivity or inhibition of collagenation may help antagonize against liver fibrosis development (An et al.
Conversely, pronounced morphological alterations occurred in alcohol-treated rats, including fat deposition, collagenation
, hepatocellular degeneration, inflammatory responses and necrosis, which were accompanied by a reduction in cell number (Fig.
In dead space wound model also the weight of the granulation tissue of the lupeol treated animal was increased indicating increase of collagenation and absence of monocytes.
Wound healing is a highly ordered and well coordinated process that involves inflammation, cell proliferation, matrix deposition, tissue remodeling, collagenation and epithelialization.
granulation, collagenation, collagen maturation and scar maturation (Cherry et al.
The better collagenation seen under the influence of this plant extract may also be due to the improved antioxidant status.