matrix metalloproteinase 13

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matrix metalloproteinase 13

An enzyme encoded on chromosome 11q22.3 which degrades extracellular matrix and other tissue substrates.

Cytokine inducers
EGF, FGF-b, FGF-7, IGF-1, IL-1β, IL-6, IL-13, LIF, oncostatin M, PDGF, PDGF-BB, TGF-α, TGF-β1, TGF-β2, TNF-α.
 
Substrates
Collagens I, II and III, IV, IX, X and XIV; gelatin, α1-ACHYM and plasminogen activator inhibitor 2; aggrecan; perlecan; large tenascin-C and fibronectin; osteonectin; MMP-9.