collagenase

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collagenase

 [kŏ-laj´ĕ-nās]
an enzyme that catalyzes the degradation of collagen.

col·la·gen·ase

(kol-ăj'ĕ-nās),
A proteolytic enzyme that acts on one or more of the collagens.

collagenase

/col·la·ge·nase/ (kah-laj´ĕ-nās) an enzyme that catalyzes the hydrolysis of peptide bonds in triple helical regions of collagen.

collagenase

(kə-lăj′ə-nās′, -nāz′, kŏl′ə-jə-)
n.
Any of various enzymes that catalyze the hydrolysis of collagen and gelatin.

collagenase

[kəlaj′ənās]
a medication applied as an ointment for debridement of decubitus ulcers, burns, and other epidermal lesions. It is also injected into the penis for treatment of Peyronie's disease and into the wrist, ankle, etc. for the treatment of Dupuytren's disease (restricted movement caused by thickening of the fascia). It is an enzyme preparation derived from the fermentation of Clostridium histolyticum.

matrix metalloproteinase 1

A 43-kD tissue enzyme (EC 3.4.24.7), encoded by MMP1 on chromosome 11q21-q22, which cleaves collagens, cytokines and extracellular matrix.

Cytokine inducers 
BTC, CD40L, EGF, FGF-a, FGF-b, FGF-7, FGF-9, GM-CSF, HGF, HRG-β1, IFN-β, IFN-γ, IL-1α, IL-1β, IL-4, IL-5, IL-6, sIL-6 Rα, IL-8, IL-10, MIF, oncostatin M, PD-ECGF, PDGF, PDGF-AA, PDGF-BB, PF4, TGF-α, TGF-β1, TNF-α, TNF-β, VEGF.
 
Substrates
3 α-chains of native Collagens I, II, III, VII, VIII and IX; gelatin, aggrecan, hyaluronidase-treated versican, proteoglycan link protein, large tenascin-C, α1-antitrypsin/α1-proteinase inhibitor (α1-AT), α1-antichymotrypsin, pregnancy zone protein, ovostatin, entactin/nidogen, MBP, GST-TNF/TNF peptide, l-selectin, serum amyloid A, IGF-BP3, IGF-BP5, IL-1β, MMP-2, MMP-9.

col·lag·en·ase

(kŏ-laj'ĕ-nās)
A proteolytic enzyme that acts on one or more of the collagens.

col·lag·en·ase

(kŏ-laj'ĕ-nās)
A proteolytic enzyme that acts on collagens.

collagenase (kol´əjənās´),

n an enzyme capable of depolymerizing collagen, found in some microorganisms and believed to contribute to periodontal disease.

collagenase

an enzyme that catalyzes the degradation of collagen.

collagenase ulceration
a rapidly spreading ulceration of the cornea triggered by the liberation of collagenase from necrotic cells.