collagenase


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collagenase

 [kŏ-laj´ĕ-nās]
an enzyme that catalyzes the degradation of collagen.

col·la·gen·ase

(kol-ăj'ĕ-nās),
A proteolytic enzyme that acts on one or more of the collagens.

collagenase

/col·la·ge·nase/ (kah-laj´ĕ-nās) an enzyme that catalyzes the hydrolysis of peptide bonds in triple helical regions of collagen.

collagenase

(kə-lăj′ə-nās′, -nāz′, kŏl′ə-jə-)
n.
Any of various enzymes that catalyze the hydrolysis of collagen and gelatin.

collagenase

[kəlaj′ənās]
a medication applied as an ointment for debridement of decubitus ulcers, burns, and other epidermal lesions. It is also injected into the penis for treatment of Peyronie's disease and into the wrist, ankle, etc. for the treatment of Dupuytren's disease (restricted movement caused by thickening of the fascia). It is an enzyme preparation derived from the fermentation of Clostridium histolyticum.

matrix metalloproteinase 1

A 43-kD tissue enzyme (EC 3.4.24.7), encoded by MMP1 on chromosome 11q21-q22, which cleaves collagens, cytokines and extracellular matrix.

Cytokine inducers 
BTC, CD40L, EGF, FGF-a, FGF-b, FGF-7, FGF-9, GM-CSF, HGF, HRG-β1, IFN-β, IFN-γ, IL-1α, IL-1β, IL-4, IL-5, IL-6, sIL-6 Rα, IL-8, IL-10, MIF, oncostatin M, PD-ECGF, PDGF, PDGF-AA, PDGF-BB, PF4, TGF-α, TGF-β1, TNF-α, TNF-β, VEGF.
 
Substrates
3 α-chains of native Collagens I, II, III, VII, VIII and IX; gelatin, aggrecan, hyaluronidase-treated versican, proteoglycan link protein, large tenascin-C, α1-antitrypsin/α1-proteinase inhibitor (α1-AT), α1-antichymotrypsin, pregnancy zone protein, ovostatin, entactin/nidogen, MBP, GST-TNF/TNF peptide, l-selectin, serum amyloid A, IGF-BP3, IGF-BP5, IL-1β, MMP-2, MMP-9.

col·lag·en·ase

(kŏ-laj'ĕ-nās)
A proteolytic enzyme that acts on one or more of the collagens.

col·lag·en·ase

(kŏ-laj'ĕ-nās)
A proteolytic enzyme that acts on collagens.

collagenase (kol´əjənās´),

n an enzyme capable of depolymerizing collagen, found in some microorganisms and believed to contribute to periodontal disease.

collagenase

an enzyme that catalyzes the degradation of collagen.

collagenase ulceration
a rapidly spreading ulceration of the cornea triggered by the liberation of collagenase from necrotic cells.
References in periodicals archive ?
Injectable collagenase clostridium histolyticum for Dupuytren's contracture (CORD I).
However, the role of the APRN in the administration of intralesional collagenase Clostridium histolyticum is unclear at this time.
The results of in-vitro collagenase degradation at different time intervals are presented in Fig.
The formulation, made up of two collagenases naturally produced by the bacterium Clostridium histolyticum, is injected into the cord at 4-week intervals, for a maximum of three injections), according to the manufacturer, Auxilium Pharmaceuticals Inc.
Modified proenzymes as artificial substrates for proteolytic enzymes: a colorimetric assay of bacterial collagenase and matrix metal loproteinase activity using modified pro-urokinase.
2] while the SNP did not, The ELISA showed that both SNP and GSNO (1mM) decreased expression of elastin, collagenase.
Bulk electrocyte preparations were produced by incubating whole electric organs in an equal volume of skate saline containing 1% (w/v) collagenase (Worthington CLS I) for up to 7 days at 6 [degrees] C.
Collagenase SANTYL([R]) Ointment is a selective enzymatic debriding agent that contains 250 collagenase units per gram of white petrolatum USP.
After several repeated attempts, we decided to isolate ADSCs using secondary collagenase digestion.
But Fuller warned the audience that anti-aging compounds must block collagenase yet stimulate collagen expression in aging fibroblasts.
Although all patients had detectable antibodies to collagenase by their third collagenase injection, no systemic allergic reactions were reported.
2) Triphala allows suppression of collagenase activity well within the safety profile of toxicological studies (Sajith Abraham 2005).