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collagenase

   Also found in: Dictionary/thesaurus, Acronyms, Encyclopedia, Wikipedia 0.01 sec.
collagenase /col·la·ge·nase/ (kah-laj´ĕ-nās) an enzyme that catalyzes the hydrolysis of peptide bonds in triple helical regions of collagen.
col·lag·e·nase (k-lj-ns, -nz, kl-j-)
n.
Any of various enzymes that catalyze the hydrolysis of collagen and gelatin.

collagenase
[kəlaj′ənās]
a medication applied as an ointment for debridement of decubitus ulcers, burns, and other epidermal lesions. It is also injected into the penis for treatment of Peyronie's disease and into the wrist, ankle, etc. for the treatment of Dupuytren's disease (restricted movement caused by thickening of the fascia). It is an enzyme preparation derived from the fermentation of Clostridium histolyticum.

collagenase [kŏ-laj´ĕ-nās]
an enzyme that catalyzes the degradation of collagen.

collagenase (kol´jnās´),
n an enzyme capable of depolymerizing collagen, found in some microorganisms and believed to contribute to periodontal disease.

collagenase
an enzyme that catalyzes the degradation of collagen.

collagenase ulceration
a rapidly spreading ulceration of the cornea triggered by the liberation of collagenase from necrotic cells.


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To dissect the underlying control mechanisms for this process, we established a keratinocyte/fibroblast co-culture system and subsequently demonstrated more than a 10-fold increase in collagenase expression in fibroblasts co-cultured with keratinocytes relative to that of control cells.
Therefore, we studied the involvement of iron and ROS in the modulation of Jun N-terminal kinase 2 (JNK2) activity, c-jun and c-fos mRNA levels, key signaling steps in the transcriptional control of matrix-degrading metalloprotease (MMP)-1/interstitial collagenase and MMP-3/stromelysin-1 after UVB irradiation of human dermal fibroblasts in vitro.
Matrix metalloproteinase-1 (MMP-1) is a collagenase (it is also called 'interstitial collagenase') that acts on native (i.
 
 
 
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