collagenase


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Related to collagenase: elastase, hyaluronidase, trypsin, collagenase clostridium histolyticum

collagenase

 [kŏ-laj´ĕ-nās]
an enzyme that catalyzes the degradation of collagen.

col·la·gen·ase

(kol-ăj'ĕ-nās),
A proteolytic enzyme that acts on one or more of the collagens.

collagenase

/col·la·ge·nase/ (kah-laj´ĕ-nās) an enzyme that catalyzes the hydrolysis of peptide bonds in triple helical regions of collagen.

collagenase

(kə-lăj′ə-nās′, -nāz′, kŏl′ə-jə-)
n.
Any of various enzymes that catalyze the hydrolysis of collagen and gelatin.

collagenase

[kəlaj′ənās]
a medication applied as an ointment for debridement of decubitus ulcers, burns, and other epidermal lesions. It is also injected into the penis for treatment of Peyronie's disease and into the wrist, ankle, etc. for the treatment of Dupuytren's disease (restricted movement caused by thickening of the fascia). It is an enzyme preparation derived from the fermentation of Clostridium histolyticum.

matrix metalloproteinase 1

A 43-kD tissue enzyme (EC 3.4.24.7), encoded by MMP1 on chromosome 11q21-q22, which cleaves collagens, cytokines and extracellular matrix.

Cytokine inducers 
BTC, CD40L, EGF, FGF-a, FGF-b, FGF-7, FGF-9, GM-CSF, HGF, HRG-β1, IFN-β, IFN-γ, IL-1α, IL-1β, IL-4, IL-5, IL-6, sIL-6 Rα, IL-8, IL-10, MIF, oncostatin M, PD-ECGF, PDGF, PDGF-AA, PDGF-BB, PF4, TGF-α, TGF-β1, TNF-α, TNF-β, VEGF.
 
Substrates
3 α-chains of native Collagens I, II, III, VII, VIII and IX; gelatin, aggrecan, hyaluronidase-treated versican, proteoglycan link protein, large tenascin-C, α1-antitrypsin/α1-proteinase inhibitor (α1-AT), α1-antichymotrypsin, pregnancy zone protein, ovostatin, entactin/nidogen, MBP, GST-TNF/TNF peptide, l-selectin, serum amyloid A, IGF-BP3, IGF-BP5, IL-1β, MMP-2, MMP-9.

col·lag·en·ase

(kŏ-laj'ĕ-nās)
A proteolytic enzyme that acts on one or more of the collagens.

col·lag·en·ase

(kŏ-laj'ĕ-nās)
A proteolytic enzyme that acts on collagens.

collagenase (kol´əjənās´),

n an enzyme capable of depolymerizing collagen, found in some microorganisms and believed to contribute to periodontal disease.

collagenase

an enzyme that catalyzes the degradation of collagen.

collagenase ulceration
a rapidly spreading ulceration of the cornea triggered by the liberation of collagenase from necrotic cells.
References in periodicals archive ?
A one-step sandwich enzyme immunoassay for inactive precursor and complexed forms of human matrix metalloproteinase 9 (92 kDa gelatinase/type IV collagenase, gelatinase B) using monoclonal antibodies.
Note to the members of the standing committee on medicinal products for human use/standing committee on veterinary medicinal products: Adoption of COMMISSION IMPLEMENTING DECISION granting marketing authorisation under Regulation (EC) No 726/2004 of the European Parliament and of the Council for "Xiapex - collagenase clostridium histolyticum", a medicinal product for human use.
Major Finding: The first injection of collagenase C.
Collagenase is a protease that is specific to collagen.
Our finding on the effectiveness of the collagenase on the retrieval of ovarian follicles of different sizes (from 150 [micro]m to 1,000 [micro]m) used was supported by other reports (Morbeck et al.
For technical data and manufacturing plants analysis, the report analyzes Collagenase leading suppliers on capacity, commercial production date, manufacturing plants distribution, R&D status, technology sources, and raw materials sources.
The formulation, made up of two collagenases produced by the bacterium Clostridium histolyticurn, is injected into the cord at 4-week intervals, for a maximum of three injections, according to the manufacturer, Auxilium Pharmaceuticals Inc.
Collagenase SANTYL([R]) Ointment is a selective enzymatic debriding agent that contains 250 collagenase units per gram of white petrolatum USP.
BB-2827, a collagenase inhibitor for inflammation, huN901-DM1, a targeted cytotoxic for small cell lung cancer, and BB-76163, an aminopeptidase inhibitor for chronic inflammatory disease, are in preclinical development.
Smith &Nephew, the global medical device company, today announced the acquisition of the Collagenase product of BASF Pharma, the pharmaceutical arm of BASF AG, for a total cash consideration of (pound)74m.
Periostat is the only treatment for adult periodontitis that has been shown to suppress the tissue-destroying activity of collagenase, an enzyme overproduced by the body in response to bacterial infection in the periodontal pocket.
Collagenase breaks down collagen, which forms the structural basis of the tissues which holds a tooth in place.