ITGA2

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ITGA2

A gene on chromosome 5q11.2 that encodes an integrin alpha chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in an array of cell-cell and cell-matrix interactions, playing a major role in cell migration, organ and tissue development and differentiation. Alpha-2 beta-1 heterodimers serve as receptors for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin, and is responsible for adhesion of platelets and other cells to the extracellular matrix, modulation of collagen and collagenase gene expression and organisation of newly synthesised extracellular matrix.
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Other glycoprotein disorders include collagen receptor disorders, ADP receptor disorders and Platelet-Type VWD (also called Pseudo-VWD), in which an unusual gain-of-function abnormality of GP lb leads to increased binding of platelet GP IbN/IX to von Willebrand factor.
6] Platelet collagen receptor glycoprotein VI (pGPVI) is the key regulator of platelet activation and aggregation at sites of vascular injury where collagen is exposed (1, 2).
On the one hand, activated platelets show enhanced surface expression of collagen receptor pGPVI in ACS as determined by flow cytometry, in accordance with previous findings (4, 5).
Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor.
Several collagen receptors have been identified on the platelet surface.
Collagenase is the drug which binds on the collagen receptor.
This was accompanied by reduced tyrosine phosphorylation of the tyrosine kinase Syk and phospholipase Cgamma2, components of the platelet glycoprotein VI collagen receptor signaling pathway.
In contrast, in patients with von Willebrand disease (VWD) type I and borderline to normal ristocetin-cofactor (von Willebrand factor [VWF]:RCo) activity, collagen receptor density correlates inversely with closure time in a high-shear-stress system, that is, the Platelet Function Analyzer (PFA-100, Dade-Behring, Deerfield, Ill).
said, "SAN-300 targets a major collagen receptor, VLA-1 (11 integrin), and has shown activity in multiple preclinical models of inflammation.
Recent advances in thrombosis and hemostasis: platelet collagen receptors.
2] synthesis from blood cell membrane-derived AA in addition to binding to known collagen receptors, including the glycoprotein GpVI/Fc receptor [gamma]-chain complex.