sodium powder for solution for injection or infusion 1 miu 50.
Either international units or milligrams of the sodium salt colistimethate
(the inactive prodrug) may be used, and to confuse matters further, colistin base activity (CBA) in milligrams may also be used to define the dose.
is hydrolysed to colistin, a cationic agent that acts by increasing permeability of cell membrane and leading to cell death.
Polymyxin B and colistimethate
are comparable as to efficacy and renal toxicity.
sodium was administered as recommended in the literature in three equal doses of 5 mg/kg per day, 12 hours after a single 5 mg/kg loading dose.
Of note, polymyxin-containing batches from commercial origin can be used, but the colistimethate
sulfate powder, a therapeutic prodrug of colistin, cannot be used.
Xellia is a supplier of vancomycin and colistimethate
sodium which together combat multi-drug resistant bacterial infections across Gram-positive and Gram-negative species.
Confusion of terms: there are two forms of colistin available: colistin sulfate for topical and digestive use, and colistimethate
sodium (CMS), for parenteral use; these are not interchangeable.
(colistin) use in critically ill children without cystic fibrosis.
This was the case with sodium colistimethate
(originally classified as both A and J, but assigned by the authors to category J), dimentidene (originally D and R, assigned to R), flutrimazole (originally D and G, assigned to G), and eflornithine hydrochloride (originally D and P, assigned to P).
APP's version, called Colistimethate
, will be shipped immediately, the company said.
Sol, 50-, 150-, 450- and 600; ZenChent (EE/norethindrone); colistimethate