46 AA(R) resolution structure of the pancreatic lipase colipase
complex inhibited by a C11 alkyl phosphonate.
Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase
gene and type 2 diabetes mellitus in two independent Caucasian study populations.
The importance of bile salt for the reactivation of pancreatic lipase by colipase
0 and partially purified broiler colipase (BROCKMAN, 1981).
The digestion and absorption of lipids require several factors, such as the presence of bile salts, pancreatic lipase, colipase, and fatty acid binding protein.
Secretion of pancreatic lipase and colipase
from rat pancreas.
2) However, contemporary lipase assays now contain colipase
and bile salts that increase the analytical sensitivity of lipase assays.
All four experimental methods (experimental reagents from Sentinel) contained colipase, but differed from one another in stabilizing proteins and in the size of substrate micelles: two methods contained protein (0.
Our data show that, for the lipase assays that use 1,2-o-dilauryl-rac-glycero-3-glutaric acid- (6'-methylresorufin) ester as substrate, the frequency of noncommutability may be affected by some characteristics of the analytical method, such as size of substrate micelles and the presence of stabilizing proteins different from colipase.
Serum lipase activity increased in all our patients without a parallel increase in serum amylase titers; the combination of accurate clinical, biochemical, and instrumental study of these patients allowed us to exclude the possibility of a normoamylasemic pancreatic injury, and the presence of appropriate concentrations of bile salts and colipase
in the reagent favors a full and specific action of lipase assay, at the same time inhibiting serum esterase (8).
In the small intestine lipolysis is completed by pancreatic lipase acting with colipase
as cofactor and absorption of lipolytic products starts.