colipase


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co·lip·ase

(kō'lip-ās),
A small protein in pancreatic juice essential for the efficient action of pancreatic lipase. This cofactor inhibits the surface denaturation of the lipase.
[co- + lipase]

co·lip·ase

(kō'lip-ās)
A small protein in pancreatic juice that is essential for the efficient action of pancreatic lipase.
References in periodicals archive ?
Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations.
2) However, contemporary lipase assays now contain colipase and bile salts that increase the analytical sensitivity of lipase assays.
All four experimental methods (experimental reagents from Sentinel) contained colipase, but differed from one another in stabilizing proteins and in the size of substrate micelles: two methods contained protein (0.
Our data show that, for the lipase assays that use 1,2-o-dilauryl-rac-glycero-3-glutaric acid- (6'-methylresorufin) ester as substrate, the frequency of noncommutability may be affected by some characteristics of the analytical method, such as size of substrate micelles and the presence of stabilizing proteins different from colipase.
Serum lipase activity increased in all our patients without a parallel increase in serum amylase titers; the combination of accurate clinical, biochemical, and instrumental study of these patients allowed us to exclude the possibility of a normoamylasemic pancreatic injury, and the presence of appropriate concentrations of bile salts and colipase in the reagent favors a full and specific action of lipase assay, at the same time inhibiting serum esterase (8).
In the small intestine lipolysis is completed by pancreatic lipase acting with colipase as cofactor and absorption of lipolytic products starts.