cold nodule

cold nod·ule

a thyroid nodule with a much lower uptake of radioactive iodine than the surrounding parenchyma; about one in four prove to be malignant.

cold nodule

Imaging A focus of ↓ radioisotope uptake on a 123I or 99mTc scintillation scan of the thyroid, seen in cystic or solid, often nonfunctional lesions; when the mass is solid by ultrasound, a biopsy is warranted as most carcinomas are cold nodules. Cf Hot nodule, Warm nodule.

cold nod·ule

(kōld nod'yūl)
A thyroid nodule with a much lower uptake of radioactive iodine than the surrounding parenchyma; about one in four proves to be malignant.
References in periodicals archive ?
Economic and an accurate procedure used in the diagnosis of thyroid Lesions, particularly in the presence of cold nodule [1].
131] I scintigraphy will show a poorly defined cold nodule.
A solitary third or fourth branchial cyst may be contained completely within the thyroid gland and may present as a cold nodule.
Thyroid carcinoma usually presents as a cold nodule on nuclear medicine scans.
Overall, a cold nodule was associated with a significantly higher incidence of malignancy than was a hot nodule (sensitivity = 91%; specificity = 19%; accuracy = 38%; [chi square] = 7.
Comparison of initial findings with final surgical pathology (n [%]) in 243 patients who underwent diagnostic scintigraphy Final surgical pathology Initial finding Malignant Benign Cold nodule (n = 189) 52 (27.
We also compared the incidence of cancer among patients with cold nodules with its incidence among patients with all other findings on scintigraphy (table 2).
Cold nodules in patients who are younger can carry a malignancy rate of up to 35% to 40%.
Miller E, Varatharajah R, et al: Thyroid carcinoma in single cold nodules and in cold nodules of multinodular goiters.