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cold nodule

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cold nodule
Imaging A focus of ↓ radioisotope uptake on a 123I or 99mTc scintillation scan of the thyroid, seen in cystic or solid, often nonfunctional lesions; when the mass is solid by ultrasound, a biopsy is warranted as most carcinomas are cold nodules. Cf Hot nodule, Warm nodule.


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Cold nodules in patients who are younger can carry a malignancy rate of up to 35% to 40%.
131] I scintigraphy will show a poorly defined cold nodule.
Overall, a cold nodule was associated with a significantly higher incidence of malignancy than was a hot nodule (sensitivity = 91%; specificity = 19%; accuracy = 38%; [chi square] = 7.
 
 
 
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