cold hypersensitivity

cold hypersensitivity

 An excess autonomic nervous system reaction to low ambient temperature, characterized by bradycardia and a local wheal-and-flare reaction; when familial, the reaction is termed 'cold urticaria'
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TRPV1 antagonists make patients temporarily blind to heat, which Zylka speculates is analogous to what happened when his lab deleted the animals' circuit that detects heat: cold hypersensitivity.
Among them are hypertension, alkaptonuria, systemic chondromalacia, relapsing polychondritis, and familial cold hypersensitivity.