Most are held in place by proteins called CTCF and cohesin
Germline Gain-of-Function Mutations in AFF4 Cause a Novel Syndrome and Functionally Link the Super Elongation Complex and Cohesin
," Nature Genetics, published online March 2, 2015.
SMC1A encodes a protein that is part of the cohesin
protein complex and is involved in sister chromatid cohesion during the cell cycle (Bauerschmidt et al.
Through examinations of patients suffering from myelodysplastic syndrome, a type of myelogenetic blood cancer, the team found that four types of genes -- which produce the cohesin
protein complex that coordinates gene action -- suppress the growth of cancer cells.
One new area of interest that the work points towards is genes involved in the cohesin
complex, a group of proteins that helps shepherd chromosomes into the right place throughout cell division.
This finding is in agreement with the conclusion that the counter-tension produced by the cleavage of the kleisin subunit of cohesin
observed when all sister chromatids are in mitosis (Jones, 2010) or all bivalents are in meiosis (Dumont et al.
By tracking chromosomes during division in the egg, the Newcastle team found that the reduced Cohesin
in eggs from older females resulted in some chromosomes becoming trapped and being unable to divide properly.
In a study led my Dr Mary Herbert, and funded by Newlife Foundation for Disabled Children, Infertility Research Trust, and the MRC, researchers at Newcastle University and Newcastle Fertility Centre, used eggs from young and old mice to show that Cohesin
levels decline gradually as females get older.
Recently loss-of-function mutations in members of the cohesin
complex have been described in up to 15% of patients with AML.
The CdLS research team at Children's Hospital has focused on the cohesin
complex, a group of proteins that form a bracelet-like structure that encircles pairs of chromosomes, called sister chromatids.
If there is too little cohesin
, the structure can be too "floppy" for division to happen equally.
would be associated with sister chromatids.