coenzyme Q-10


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coenzyme Q-10

(ko-en-zime-cue-ten) ,

coQ10

(trade name),

ubiquinol

(trade name),

ubiquinone

(trade name)

Classification

Therapeutic: antioxidants
Heart failureCoenzyme Q–10 deficiencyMitochondrial disorders Muscular dystrophyImmune stimulant in HIV infectionParkinson's disease

Action

A co-factor in oxidative respiration for the Krebs cycle and the electron transport chain important for mitochondrial ATP generation. It also has antioxidant activity and membrane stabilizing ability.

Therapeutic effects

Antioxidant effects.

Pharmacokinetics

Absorption: Poor absorption in the GI tract, absorbed primarily in the small intestine.
Distribution: Unknown.
Metabolism and Excretion: Metabolized in all tissues, elimination via biliary and fecal excretion.
Half-life: 34 hrs.

Time/action profile

ONSETPEAKDURATION
POUnknown5–10 hrsUnknown

Contraindications/Precautions

Contraindicated in: Obstetric: Pregnancy and lactation; Allergy/hypersensitivity.
Use Cautiously in: Hypotension; Surgery (discontinue 2 weeks prior to procedure).

Adverse Reactions/Side Effects

Central nervous system

  • dizziness

Cardiovascular

  • hypotension

Dermatologic

  • rash

Gastrointestinal

  • nausea
  • vomiting
  • diarrhea
  • heartburn
  • decreased appetite

Interactions

HMG CoA reductase inhibitors (statins) can ↓ coenzyme Q-10 levels.May ↑ risk of clotting with anticoagulants.May have additive hypotensive effects with antihypertensives.May protect againstanthracycline -associated cardiotoxicity.Red yeast can ↓ coenzyme Q-10 levels.May have additive hypotensive effects with herbs that can lower BP including fish oil and L-arginine.
Oral (Adults) Coenzyme Q-10 deficiency—150 mg daily; Mitochondrial disorders—150–160 mg daily or 2 mg/kg/day; Heart failure—60–100 mg daily; HIV/AIDS—200 mg daily; Parkinson's disease—300–2400 mg daily; Muscular dystrophy—100 mg daily.

Availability

Soft-gel capsules:
Tablets:

Nursing implications

Nursing assessment

  • Monitor BP periodically during therapy.
  • Lab Test Considerations: Monitor coagulation studies periodically during therapy.
    • Monitor blood glucose during therapy; may cause hypoglycemia.
    • Monitor lipid levels and serum lactate periodically during therapy.

Potential Nursing Diagnoses

Activity intolerance

Implementation

  • Oral: Administer with a meal containing fat for optimal absorption.

Patient/Family Teaching

  • Instruct patient to take with a meal containing fat, as directed.
  • May cause dizziness. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.

Evaluation/Desired Outcomes

  • Antioxidant effects in a variety of conditions.

coenzyme Q-10

n.
A form of coenzyme Q containing 10 isoprene units that is the most common form in animals and is used as a dietary supplement for its purported antioxidant properties.
References in periodicals archive ?
It contains the ingredients Coenzyme Q-10 and Hyaluronic Acid, that are found in many specialty and high-end anti-aging products, but what's great is that you're getting it at a fraction of the cost - this product is under $3.
CoQ-10, also known as CoEnzyme Q-10, is an essential cellular component that promotes energy production, and numerous studies have shown it plays a key role in promoting cardiovascular health.
Essence of Youth provides an essential daily formula supported by Coenzyme Q-10, Royal Jelly, RNA/DNA and Inositol, which have shown to be anti-aging.
It has been reported that approximately three billion dollars ($3,000,000,000) is being spent annually in the US alone on antioxidants such as vitamins A, C and E and Coenzyme Q-10 to fight oxidation.
OTCBB:AHRX) announced today it will present the results of its human clinical trial on Coenzyme Q-10 in a research paper entitled "Increased Bioavailability of Coenzyme Q-10 In Self-Emulsifying Controlled Release Tablet: New Type of Delivery System for Hydrophobic Drugs" at the 28th Controlled Release Society Symposium.
The proprietary formula contains high concentrations of polyphenols, Coenzyme Q-10 and Vitamin E.
Patent 4,654,373 titled "Pharmaceutical Formulation Containing Coenzyme Q-10 Suitable for Topical Administration" from Italfarmaco S.
Coenzyme Q-10 -- Known as the gold standard in moisturization and overall revitalization, coenzyme Q-10 is found in many high-end and specialty anti-aging products.
We offer a full line of products, consisting of vitamin and mineral, joint health, herbal, and specialty products, including our newest product, Resveratrol Coenzyme Q-10 Complex.
After just four weeks of being treated with CoEnzyme Q-10 supplementation, her name was removed from the list.
Containing Red Yeast Rice, Policonsanol and CoEnzyme Q-10, this blend supports levels of "good" cholesterol, boosts the immune system, and energizes the heart.