coenzyme Q-10


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coenzyme Q-10

(ko-en-zime-cue-ten) ,

coQ10

(trade name),

ubiquinol

(trade name),

ubiquinone

(trade name)

Classification

Therapeutic: antioxidants
Heart failureCoenzyme Q–10 deficiencyMitochondrial disorders Muscular dystrophyImmune stimulant in HIV infectionParkinson's disease

Action

A co-factor in oxidative respiration for the Krebs cycle and the electron transport chain important for mitochondrial ATP generation. It also has antioxidant activity and membrane stabilizing ability.

Therapeutic effects

Antioxidant effects.

Pharmacokinetics

Absorption: Poor absorption in the GI tract, absorbed primarily in the small intestine.
Distribution: Unknown.
Metabolism and Excretion: Metabolized in all tissues, elimination via biliary and fecal excretion.
Half-life: 34 hrs.

Time/action profile

ONSETPEAKDURATION
POUnknown5–10 hrsUnknown

Contraindications/Precautions

Contraindicated in: Obstetric: Pregnancy and lactation; Allergy/hypersensitivity.
Use Cautiously in: Hypotension; Surgery (discontinue 2 weeks prior to procedure).

Adverse Reactions/Side Effects

Central nervous system

  • dizziness

Cardiovascular

  • hypotension

Dermatologic

  • rash

Gastrointestinal

  • nausea
  • vomiting
  • diarrhea
  • heartburn
  • decreased appetite

Interactions

HMG CoA reductase inhibitors (statins) can ↓ coenzyme Q-10 levels.May ↑ risk of clotting with anticoagulants.May have additive hypotensive effects with antihypertensives.May protect againstanthracycline -associated cardiotoxicity.Red yeast can ↓ coenzyme Q-10 levels.May have additive hypotensive effects with herbs that can lower BP including fish oil and L-arginine.
Oral (Adults) Coenzyme Q-10 deficiency—150 mg daily; Mitochondrial disorders—150–160 mg daily or 2 mg/kg/day; Heart failure—60–100 mg daily; HIV/AIDS—200 mg daily; Parkinson's disease—300–2400 mg daily; Muscular dystrophy—100 mg daily.

Availability

Soft-gel capsules:
Tablets:

Nursing implications

Nursing assessment

  • Monitor BP periodically during therapy.
  • Lab Test Considerations: Monitor coagulation studies periodically during therapy.
    • Monitor blood glucose during therapy; may cause hypoglycemia.
    • Monitor lipid levels and serum lactate periodically during therapy.

Potential Nursing Diagnoses

Activity intolerance

Implementation

  • Oral: Administer with a meal containing fat for optimal absorption.

Patient/Family Teaching

  • Instruct patient to take with a meal containing fat, as directed.
  • May cause dizziness. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.

Evaluation/Desired Outcomes

  • Antioxidant effects in a variety of conditions.

coenzyme Q-10

n.
A form of coenzyme Q containing 10 isoprene units that is the most common form in animals and is used as a dietary supplement for its purported antioxidant properties.
References in periodicals archive ?
Therapy with coenzyme Q-10 of patients in heart failure who are eligible or ineligible for a transplant.
Clinical trial with water-soluble CoQ-10 Effect of hydrosoluble coenzyme Q-10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease (Journal of Hypertension, Mar 1999): In this randomized double-blind placebo-controlled trial among patients receiving antihypertensive medication and with coronary artery disease (n=59: 30 in treatment group, 29 in placebo group), patients received oral coenzyme Q-10 (60 mg twice daily) for 8 weeks.
There are plenty of other substances with preliminary potential for helping prevent heart disease, but with less research to go on, including L-arginine, coenzyme Q-10 red yeast rice powder and guggulipid.
2%), garlic supplements (11%), and coenzyme Q-10 (8.
In 2003 we were ahead of the curve when we launched our coenzyme Q-10 in 300 mg," Pigott says.
Enhanced blood levels of coenzyme Q-10 from an emulsified oral form.
It contains the ingredients Coenzyme Q-10 and Hyaluronic Acid, that are found in many specialty and high-end anti-aging products, but what's great is that you're getting it at a fraction of the cost - this product is under $3.
Specifically, those ingredients and technologies include hyaluronic spheres, coenzyme Q-10 and light refractors.
For example, in the hand & body segment firming capability is key, while facial products have benefited from the addition of the coenzyme Q-10 antiwrinkle ingredient.
CoQ-10, also known as CoEnzyme Q-10, is an essential cellular component that promotes energy production, and numerous studies have shown it plays a key role in promoting cardiovascular health.