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coenzyme Q-10(ko-en-zime-cue-ten) ,
Heart failureCoenzyme Q–10 deficiencyMitochondrial disorders Muscular dystrophyImmune stimulant in HIV infectionParkinson's disease
A co-factor in oxidative respiration for the Krebs cycle and the electron transport chain important for mitochondrial ATP generation. It also has antioxidant activity and membrane stabilizing ability.
Absorption: Poor absorption in the GI tract, absorbed primarily in the small intestine.
Metabolism and Excretion: Metabolized in all tissues, elimination via biliary and fecal excretion.
Half-life: 34 hrs.
Contraindicated in: Obstetric: Pregnancy and lactation; Allergy/hypersensitivity.
Use Cautiously in: Hypotension; Surgery (discontinue 2 weeks prior to procedure).
Adverse Reactions/Side Effects
Central nervous system
- decreased appetite
InteractionsHMG CoA reductase inhibitors (statins) can ↓ coenzyme Q-10 levels.May ↑ risk of clotting with anticoagulants.May have additive hypotensive effects with antihypertensives.May protect againstanthracycline -associated cardiotoxicity.Red yeast can ↓ coenzyme Q-10 levels.May have additive hypotensive effects with herbs that can lower BP including fish oil and L-arginine.
Oral (Adults) Coenzyme Q-10 deficiency—150 mg daily; Mitochondrial disorders—150–160 mg daily or 2 mg/kg/day; Heart failure—60–100 mg daily; HIV/AIDS—200 mg daily; Parkinson's disease—300–2400 mg daily; Muscular dystrophy—100 mg daily.
- Monitor BP periodically during therapy.
- Lab Test Considerations: Monitor coagulation studies periodically during therapy.
- Monitor blood glucose during therapy; may cause hypoglycemia.
- Monitor lipid levels and serum lactate periodically during therapy.
Potential Nursing DiagnosesActivity intolerance
- Oral: Administer with a meal containing fat for optimal absorption.
- Instruct patient to take with a meal containing fat, as directed.
- May cause dizziness. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.
- Antioxidant effects in a variety of conditions.
A form of coenzyme Q containing 10 isoprene units that is the most common form in animals and is used as a dietary supplement for its purported antioxidant properties.