cocarcinogen

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cocarcinogen

 [ko″kahr-sin´o-jen]
an agent that increases the effect of a carcinogen by direct concurrent local effect on the tissue.

co·car·cin·o·gen

(kō-kar-sin'ō-jen'),
A substance that works symbiotically with a carcinogen in the production of cancer.

cocarcinogen

/co·car·cin·o·gen/ (ko″kahr-sin´o-jen) promoter (3).

cocarcinogen

(kō′kär-sĭn′ə-jən, kō-kär′sĭn-ə-jĕn′)
n.
A substance or factor that will not promote cancer by itself but can potentiate cancer when acting with carcinogenic agents.

co·car′cin·o·gen′ic (-sə-nə-jĕn′ĭk) adj.

cocarcinogen

[kōkär′sənəjən]
Etymology: L, cum, together with; Gk, karkinos, crab, genein, to produce
an agent that alone does not transform a normal cell into a cancerous state but in concert with another agent can effect the transformation.

co·car·cin·o·gen

(kō'kahr-sin'ō-jen)
A substance that works symbiotically with a carcinogen in the production of cancer.

cocarcinogen

an agent that increases the effect of a carcinogen by direct concurrent local effect on the tissue.
References in periodicals archive ?
Below, the main findings of these studies are reviewed for the benefit of the new readership, to highlight the experimental work providing strong evidence in support of a putative etiopathogenic cocarcinogenic role of SV40 in MM, despite the data from molecular and epidemiologic analyses showing moderately strong but controversial association.
70,71) In brief, the cocarcinogenic experiments, both in mice and hamsters, showed that MM did not develop in animals exposed to subcarcinogenic doses of SV40, although a few hamsters developed lymphomas and sarcomas after a prolonged latency period.
The basis of the cocarcinogenic interaction of SV40 with asbestos has been studied further in an in vitro cell culture system using primary human mesothelial cell lines.
These data provide further evidence to support the ability of As to inhibit the DNA repair machinery, which is likely to enhance the genotoxicity and mutagenicity of other directly genotoxic compounds, as part of a cocarcinogenic mechanism of action.
The marked difference in incidence of palpable tumors between MF-exposed and sham-exposed groups 13 weeks after administration of 10 mg DMBA was reduced during further exposure (22), suggesting that the MF effect was due to a tumor growth-enhancing action rather than to a cocarcinogenic effect.
Because of the high incidence of tumors in both cases, the sensitivity of these experiments to detect cocarcinogenic effects of MF exposure at the end of the study was low.
Among the reasons cited for the beneficial role of fruit and vegetables in this area are that dietary fibre decreases the body's production of secondary bile acids which have been found to be cocarcinogenic in tests conducted on rodents.
On the possible carcinogenic and cocarcinogenic action of overheated fats (review of the literature).