cocaine hydrochloride

cocaine hydrochloride

a water-soluble salt used for local anesthesia of the eye or mucous membranes.

cocaine hydrochloride

a white crystalline powder used as a local anesthetic. It was originally derived from coca leaves but can also be prepared synthetically. Cocaine is a Schedule I drug under the Controlled Substances Act of 1970.
indications In solution it is sometimes used as a topical anesthetic applied to mucous membranes. Its vasoconstrictive action slows bleeding and limits absorption. Prolonged or frequent use may damage the mucous membranes.
contraindications It is incompatible with all alkaloid precipitants, mercurials, and silver nitrate. Central nervous system overstimulation may result from use with monoamine oxidase inhibitors, amphetamines, or guanethidine. Combination with epinephrine or norepinephrine can lead to cardiac arrhythmias or ventricular fibrillation. Persons with severe cardiovascular disease, thyrotoxicosis, hypotension, or hypertension should not take this drug.
adverse reactions Among the most serious adverse reactions are excitement, depression, euphoria, restlessness, tremors, vertigo, nausea, vomiting, hypotension, hypertension, abdominal cramps, exophthalmia, mydriasis, peripheral vascular collapse, tachypnea, tachycardia, chills, fever, coma, and death from respiratory failure.
note Cocaine hydrochloride solution should be freshly made; it deteriorates rapidly on standing and cannot be heat-sterilized.
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Effect of cocaine on neurotransmission

co·caine hy·dro·chlo·ride

(kō-kān' hī'drō-klōr'īd)
A water-soluble salt used for local anesthesia of the eye or mucous membranes.

co·caine hy·dro·chlo·ride

(kō-kān' hī'drō-klōr'īd)
Water-soluble salt used for local anesthesia of the eye or mucous membranes.
References in periodicals archive ?
M2 EQUITYBITES-December 4, 2017-Lannett's NDA for Cocaine Hydrochloride Topical anesthetic solution submitted with US FDA
M2 PHARMA-December 4, 2017-Lannett's NDA for Cocaine Hydrochloride Topical anesthetic solution submitted with US FDA
Cocaine hydrochloride and LVM hydrochloride (Sigma-Aldrich, St.
FELCN reported destroying 125 cocaine hydrochloride processing labs and 4,065 rustic cocaine labs during 2016, a 19 percent increase and four percent decrease, respectively, from 2015.
Emmett Alvin Monson 6 Rosedale, NY- Offense: Conspiracy: possess with intent to distribute cocaine hydrochloride and heroin; possess with intent to distribute cocaine hydrochloride (two counts); possess with intent to distribute heroin (four counts); Middle District of North Carolina; Sentence: 360 months' imprisonment; 8 years' supervised release (September 20, 1993); Commutation Grant: Prison sentence commuted to expire on May 19, 2017.
Noe Juarez was charged with conspiracy to distribute more than five kilograms of cocaine hydrochloride, or crack cocaine, in Louisiana.
There are reports in the literature of using 4% cocaine hydrochloride treatment due to its anticholinergic effect, but to our understanding cyclopentolate has also been used in similar cases.
Compared to 2012, seizures of coca leaf decreased by 36 per cent to 476 tons, cocaine base paste by 37 per cent to 20 tons, and cocaine hydrochloride by 62 per cent to 1.
The other dangerous drugs recovered from the accused were shabu, diazepam, temazepan, ketamine, cocaine hydrochloride, methylphenidate, codeine, clonazepam and alprazolam.
McKay, an informant told Detective Tom Moreland that Jacquelyn Thompson was distributing cocaine hydrochloride from her workplace and that her son, Mark McKay, was her drug source.
The Incomplete Truth, 2006, a dove in formaldehyde, is as good a sculptural representation of a cocaine hydrochloride high as could be made; an orgasm substitute set within a quivering void (sexuality is conspicuously absent in Hirst's work).
Most important, anti-drug forces seized 12 tons of cocaine in 2006 in contrast to just three tons in 2005; 26% more cocaine base and cocaine hydrochloride than during the first nine months of 2005, and eradicated 5,000 hectares of illegal coca fields.