cocaine cardiotoxicity

cocaine cardiotoxicity

A generic term for the direct and indirect effects of cocaine on the heart.

Clinical findings
Chest pain, tachycardia, hypertension, acute myocardial infarction (MI), ventricular arrhythmia, asystole, congestive heart failure, sudden death due to cardiovascular collapse.

Direct effects
• Arrhythmias Conduction defects
• Acute MI Coronary arterial spasm; intimal hyperplasia.

Indirect effects
• Catecholamine effects Contraction band necrosis, myocardial fibrosis, and arrhythmias.

Pathogenesis
Vasoconstriction and direct cardiac toxicity.
 
Cocaine, acute effects
Contraction bands and necrosis.

Cocaine, chronic effects
• LV hypertrophy
• Fibrosis—patchy and irregular
• Intramyocardial arterial medial thickening.

cocaine cardiotoxicity

A condition caused by long-term cocaine use Clinical Chest pain, tachycardia, HTN, acute MI, ventricular arrhythmia, asystole, CHF, sudden death due to cardiovascular collapse. See Cocaine.
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References in periodicals archive ?
Importantly it was reported that apocynin can prevent cocaine-induced myocardial damage in rats [64] providing a good evidence for the therapeutic potential of Nox inhibitors in the treatment of cocaine cardiotoxicity [179].