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A widely used adjective referring to an appearance, morphology or pattern characterised by multiple, similarly-sized rounded densities that project from a single linear surface when the image is 2-D or that rise above a flattened plane when viewed in 3-D, a pattern which has been likened to pre-infernal combustion engine roads paved with ‘cobbled’ stones
Dermatology A term which referred to a common complication of pre-1990 hair replacement surgery—now of historic interest—in which the grafts are bumpy, and do not flatten with time; it is more common in patients with a tendency to form hypertrophic scars. See Hair replacement
Gastroenterology A characteristic radiologic and gross appearance of the intestinal mucosa in Crohn’s disease, due to submucosal involvement; to the endoscopist, cobblestoning refers to the uniform nodules—due to the submucosal edema—while the pathologist refers to severe ulcerative disease with crisscrossing of the ulcers through inflamed but intact mucosa; intestinal ‘cobblestoning’ may also occur in ulcerative colitis—where ulcers alternate with regenerating mucosa, ischaemic colitis, lymphoid hyperplasia of CVID, amyloidosis, mucoviscidosis, pneumatosis cystoides intestinalis, multiple lymphangiomas, and polyposis coli; in the intestine, the mucosal rugosities may correspond to polyps, or be filled with air, lymphoid tissue or amyloid
(1) A term referring to a rare roughened appearance seen by colposcopy of a uterine cervix with Neisseria gonorrhoeae
(2) A finding by hysterosalpingography characterised by rounded filling defects due to intraluminal adhesions
Imaging A term referring to a bumpiness of the greater curvature of the stomach, a finding typical of chronic hypertrophic gastritis
Oral disease A term referring to multiple, closely-set intraoral papilloma-like fibromas that impart a pebbly tactile sensation in Cowden’s premalignant multiple hamartoma syndrome
Ophthalmology Multiple sharply demarcated non-elevated lesions with prominent choroidal vessels, located between the ora serrata and equator, seen in peripheral chorioretinal atrophy, common in ageing, seen in one-fourth of all autopsies, one-third of which are bilateral; aka paving stone degeneration, senile halo
Soft tissue pathology Multiple ‘hobnail’ projections of malignant endothelial cells into the vascular lumina seen in angiosarcoma, a pattern mimicked by Kaposi sarcoma and spindle cell hemangioendothelioma
References in periodicals archive ?
Take up and remove to tip off site cobble paving - 164m2
Residents in Yarm protesting against work to replace section of cobbles with granite and York stone setts
Longer term, Coed Cymru hope to produce wooden cobbles, but new techniques will be needed again.
Riders put extra tape on their handlebars to try and dampen the effect of the cobbles but it's still a bonejarring experience.
But Stockton Council says there have been a series of inaccurate claims surrounding the plans to improve the paving around Yarm Town Hall and war memorial including suggestions that purple-coloured paving will be installed, or that all the cobbles along the whole high street would be replaced with asphalt.
I remembered last year kicking out on the cobbles and I thought I'd do the same but maybe I didn't get it right.
Andy Earnshaw, sales manager at Spectacular Driveways, says: "One of the most popular driveways replicates Cheshire Cobble and another YorKshire Flagstone.
HUNDREDS of authentic cobbles were ripped out of one of the city's World Heritage sites on "health and safety" grounds.
Riders cycled through Margery Lane, Crossgate, South Street and Grove Street, with its difficult cobbles, steep hills and sharp bends.
I refer to the very recent work done to remove dangerous cobbles in the street which have been replaced with a smooth safe surface.
The landlady grabs her by the hair, uses her to ram the door open and throws her on to the cobbles.
The cobbles are gone and heavier use means traffic lights are necessary.