MTR

(redirected from cobalamin-dependent methionine synthase)

MTR

A gene on chromosome 1q43 that encodes an enzyme which transfers a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. It then remethylates the cofactor using methyltetrahydrofolate.

Molecular pathology
Defects in MTRR cause methylcobalamin deficiency type E and folate-sensitive neural tube defects.
References in periodicals archive ?
Matthews, "Factors modulating conformational equilibria in large modular proteins: a case study with cobalamin-dependent methionine synthase," Proceedings of the National Academy of Sciences of the United States of America, vol.
Hcy is an intermediate in sulfur amino acid metabolism, and it is remethylated to Met by the folate- and cobalamin-dependent methionine synthase reaction or metabolized to Cys along the trans-sulfuration pathway (38).