coated pit


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coat·ed pit

specialized depressions on the cell surface involved in receptor-mediated endocytosis; the visible proteinaceous layer on the cytosolic side of the depression provides the coated appearance.
A specialized depression on the cytoplasmic face of the cell membrane, lined by a ‘scaffolding’ protein, clathrin. Coated pits are the 1st stage in forming a coated vesicle, which internalises and degrades receptors for VIP, insulin and other hormones. Coated pits are involved in hormone receptor-mediated endocytosis, and are pivotal in down-regulating hormone activity
References in periodicals archive ?
Tracers appeared in coated pits and large coated vesicles, endosomes of varying sizes, multivesicular bodies, and lysosomes (Hermo, 1995).
Coated pits were seen on the apical cell surface and nearby were large coated vesicles (Figs.
Coated pits are invaginations braced by special membrane-associated proteins and are used to bring material into the cell for further processing.
Coated pits, coated vesicles, and receptor-mediated endocytosis.