Coated Pit

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Coated Pit

A specialized depression on the cytoplasmic face of the cell membrane, lined by a ‘scaffolding’ protein, clathrin. Coated pits are the 1st stage in forming a coated vesicle, which internalises and degrades receptors for VIP, insulin and other hormones. Coated pits are involved in hormone receptor-mediated endocytosis, and are pivotal in down-regulating hormone activity

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