coagulation factor


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clot·ting fac·tor

any of the various plasma components involved in the clotting process.
Synonym(s): coagulation factor

coagulation factor

plasma proteins in the coagulation system that circulate as inactive zymogens or cofactors. When activated by tissue damage, they form complexes that ultimately produce thrombin, an enzyme that cleaves fibrinogen to produce a fibrin clot and stops the bleeding. See also blood clotting, coagulation, fibrinogen, hemophilia A, hemophilia B, hemophilia C, factor II through factor XIII.

coagulation factor

Blood clotting factor Hematology Any of a number of serum proteins–factors I-XIII, designated by Roman numerals, which act in a coordinated fashion to clot blood

coagulation factor

Any of the factors involved in blood clotting. The generally accepted terms for the factors and their Roman numeral designations are as follows:

factor I, fibrinogen; factor II, prothrombin; factor III, thromboplastin; factor IV, calcium (ions); factor V, proaccelerin; factor VII, serum prothrombin conversion accelerator; factor VIII, antihemophilic factor; factor IX, plasma thromboplastin component; factor X, Stuart-Prower factor; factor XI, plasma thromboplastin antecedent; factor XII, Hageman factor; factor XIII, fibrin-stabilizing factor; prekallikrein; and high-molecular-weight kininogen, also called Fitzgerald, Flaujeac, or Williams factor, or contact activation cofactor. Factor VI, once called accelerin, is no longer used.

Synonym: clotting factor See: blood coagulation
See also: factor

Patient discussion about coagulation factor

Q. What Are the Risk Factors for Developing Stroke? My father had a stroke recently, at the age of 73. What are the risk factors for developing this?

A. Primary risk factors include:

1) smoking
2) excessive alcohol intake
3) uncontrolled high blood pressure
4) high cholesterol
5) overweight/unhealthy diet
6) illegal drugs/abuse of Rx drugs
7) known or unknown heart problems
8) diabetes
9) known or unknown vascular brain defects - aneurysm, etc.
10)family history of stroke

Q. Regarding risk-factor assessment? Hello, I am……….., I heard ACSM has recently issued a new edition of its exercise guidelines. Were any changes made regarding risk-factor assessment?

A. Are you fitness professional? I understand that you are very much interested in food guidelines. It can be difficult to keep up with the latest guidelines and standards. This is particularly true this year, which has seen new USDA Food Guidelines in January, a revised Food Pyramid in May and, most recently, the release of the 7th edition of ACSM’s Guidelines for Exercise Testing and Prescription. The good news is that the ACSM risk factors have been minimally revised. For your reference, here is a summary of what has and has not changed for the 2006 edition.

Q. Is obesity a risk factor for Dementia?

A. The answer is YES. In fact, many of the risk factors for heart disease, such as high blood pressure, blood glucose levels, insulin resistance, and overweight, are also risk factors for dementia, in addition to genetic predisposition for the disease.

More discussions about coagulation factor
References in periodicals archive ?
It is important to remember that FV inhibitors may not behave clinically like other coagulation factor inhibitors and may be associated with thrombosis rather than bleeding.
Coagulation factor XIIIa substrates in human plasma: Identification and incorporation into the clot.
3%) patients include local causes, heterozygosity of inherited coagulation factor deficiency, vWD, some forms of dysfibrinogenemias, platelet function defects like release reaction abnormalities, hereditary haemorrhagic telangiectasia, allergic and other vascular purpuras, a2 antiplasmin deficiency, elevated levels of plasminogen activator, testing at inappropriate post transfusion time, high levels of one factor masking deficiency of the other and result fluctuation from time to time.
The human coagulation factor IX precursor with total 145 mutations is obtained from UniProtKB/Swiss-Prot entry [27].
These genes include Vtgs 1 and 2, choriogenins 2 and 3, ER[alpha], coagulation factor XI, transferrin, AMBP, and [beta]-actin.
Coagulation Factors 2010 - The Portfolio Aspect as Decisive Force: A Competitive Landscape and R&D Pipeline Analysis of Hemostasis Proteins
com)-- Meticulous Research announced the release of a new market research report titled, "Global Recombinant Coagulation Factors Market Outlook: 2015-2020.
It interferes with the gamma carboxylation of the vitamin K-dependent factors, which include coagulation factors II, VII, IX, and X, and the anticoagulant proteins C and S.
The dysfunction of coagulation factor VII Padua results from substitution of arginine-304 by glutamine.
A Pipeline Assessment, Market Survey and Corporate Benchmark Analysis provides a description, evaluation and assessment of the recombinant coagulation factor R&D pipelines as of October 2011.
s) supply of antihemorrhagic drugs for the treatment of haemophilia, By lots: - lot 1 - dci - coagulation factor viii; - lot 2 - dci - coagulation factor viii and factor von willebrand; - lot 3 - dci - coagulation factor viii and von willebrand factor for von willebrand disease; - lot 4 - recombinant coagulation factor viii; - lot 5 - dci - coagulation factor ix; - lot 6 - dci - nonacog alpha factor ix coagulation; - lot 7 - dci - eptacog alfa activatum; - lot 8 - dci - complex of anti-coagulation inhibitors.
Bertina has written a clear, timely, and authoritative review of factor V Leiden and other coagulation factor mutations affecting thrombotic risk (1).