coagulase

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Related to coagulase test: Indole test, Oxidase test, Catalase test

coagulase

 [ko-ag´u-lās]
a bacterial enzyme that reacts with a cofactor found in blood plasma to catalyze the formation of fibrin from fibrinogen. It is produced by most of the virulent strains of staphylococci, and by Yersinia pestis.

coagulase

/co·ag·u·lase/ (-lās) an antigenic substance of bacterial origin, produced by staphylococci, which may be causally related to thrombus formation.

coagulase

(kō-ăg′yə-lās′, -lāz′)
n.
Any of various enzymes, such as rennin or thrombin, that induce coagulation.

coagulase

[kō·ag′yəlās]
Etymology: L, coagulare, to curdle
an enzyme produced by bacteria, particularly Staphylococcus aureus, that promotes the formation of fibrin from fibrinogen to form thrombi.

coagulase

An enzyme secreted by the micro-organism Staphylococcus aureus that causes clotting in blood plasma by converting prothrombin to thrombin. This ability probably contributes to the tendency of the organism to form abscesses.

coagulase

an antigenic substance of bacterial origin, produced chiefly by staphylococci, which may be causally related to thrombus formation.

coagulase test
enzymatic conversion of fibrinogen in rabbit plasma to fibrin is used as a means of identifying pathogenic species of staphylococci. The test may be carried out rapidly on a slide or in several hours or overnight in a tube. Most coagulase-positive staphyloccoci are pathogenic; coagulase-negative ones commonly are not.
References in periodicals archive ?
9 The alternative is to wait for results from the four-hour tube coagulase test.
Clumping factor was not present and tube coagulase test results were negative.
On [ILLEGIBLE TEXT] two sets of blood cultures obtained on hospital day 2 yielded phenotypically [ILLEGIBLE TEXT] organisms, which on the basis of a positive tube coagulase test were identified as resistant S.
Atypical phenotypic characteristics, including weak or negative latex-agglutination test results, weak or negative-slide coagulase test results, heterogeneous morphologic features, slow rate of growth, and vancomycin susceptibility (by disk diffusion test) were observed.
aureus by Gram staining and by positive reactions for catalase, DNAse, and tube coagulase tests.
We applied our technology to screen a staphylococcal clinical panel, after growth in liquid medium, and found excellent correlation with culture results as well as standard coagulase tests (100% correlation).