A type of nuclear proteins that participate in the potentiation of transcription of genes that are responsive to ligand-dependent transcription factors. They belong to several families, including the p160 coactivators and the CBP/p300 molecules.
[co- + activator]
References in periodicals archive ?
Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.
Telmisartan activates a regulator of cellular energy called PPARgamma coactivator 1 alpha (PGC-1[alpha]), which stimulates the burning of excess calories.
Sytenol A not only by quenches radicals and non-radicals; it also stimulates endogenous antioxidant system and protects and maintains the integrity of mitochondria and ATP energy production by stimulating PGC1[alpha] (Peroxisome proliferator-activated receptor [gamma] coactivator 1[alpha]) which controls many aspects of oxidative metabolism, including mitochondrial biogenesis, and respiration.
GCN5-mediated transcriptional control of the metabolic coactivator PGC-1 p through lysine acetylation.
Chanarin-Dorfman syndrome: deficiency in CGI-58, a lipid droplet-bound coactivator of lipase.
We found that massage activated the mechanotransduction signaling pathways focal adhesion kinase (FAK) and extracellular signal-regulated kinase 1/2 (ERK1/2), potentiated mitochondrial biogenesis signaling [nuclear peroxisome proliferator-activated receptor [] coactivator 1[] (PGC-1[])], and mitigated the rise in nuclear factor [] B (NF[]B) (p65) nuclear accumulation caused by exercise-induced muscle trauma.
Cyclooxygenase-2 transcription is regulated by human papillomavirus 16 E6 and E7 oncoproteins: evidence of a corepressor/ coactivator exchange.
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.
There are several published studies examining the peroxisome proliferator-activated receptor gamma coactivator (PGC-1-[alpha]) response to exercise, which appears to be redox sensitive.
Estrogen receptors (ER), upon binding with estrogenic ligands assume conformations suitable for dimerization and binding with signal transmitting coactivator proteins--the ER-dimer binds to DNA and leads to transcription of target genes.
Pasinetti and colleagues found that a gene known as proliferator-activated receptor coactivator 1 (PGC-1), a key regulator of glucose currently investigated as a potential therapeutic target for Type 2 diabetes, is decreased in Alzheimer's disease.