co-carcinogen

co-carcinogen

Oncology An agent–eg, a chemical, radiation, with a 'helper' role in carcinogenesis; co-carcinogens differ from tumor promotors in that they must be present at the same time as the carcinogen. See Tumor promoter.

co-carcinogen

A substance, not in itself capable of causing cancer, that, operating in conjunction with other agents, promotes the development of cancer.
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References in periodicals archive ?
Activation might underlie the mechanism by which arsenic acts as a co-carcinogen.
Although its carcinogenic mechanism is still unknown, arsenic does not directly cause DNA damage or mutations and is therefore thought to act principally as a co-mutagen, co-carcinogen, and/or tumor promoter.
Estrogen is known to act as a co-carcinogen in human breast cancer and stimulate the proliferation of breast cancer cells.
Fiber may, help prevent certain cancers by reducing transit time in the bowel and therefore decreasing the time the bowel is exposed to potential carcinogens; holding onto water in the intestinal tract, increasing stool bulk which may dilute carcinogen concentrations in the colon; binding with bile acids in the intestinal tract, some of which could convert to co-carcinogens.
co-carcinogens that are synergistic with carcinogens;
Secondary bile acids do not themselves cause cancer, but they act as co-carcinogens, increasing the chance of cancer when coupled with true carcinogens.
Many environmental metals are co-carcinogens, eliciting their effects via inhibition of DNA repair.