clusterin


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clusterin

 [klus´ter-in]
a multifunctional glycoprotein with roles in the metabolism and transport of lipids and membrane fragments, secretion of hormones, reproductive biology, inhibition of assembly of the membrane attack complex of complement activation, programmed cell death, and modulation of intercell interactions; its expression is enhanced in tissue injury and remodeling as well as in degenerative diseases such as alzheimer's disease.

clusterin

(klŭs'tĕr-in),
Heterodimeric highly conserved secreted glycoprotein, which is expressed in a wide variety of tissues and found in all human fluids; implicated in physiologic processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis.
Synonym(s): apolipoprotein J

clusterin

[klus′terin]
a multifunctional glycoprotein with roles in the metabolism and transport of lipids and membrane fragments, secretion of hormones, reproductive biology, inhibition of assembly of the membrane attack complex of complement activation, programmed cell death, and modulation of intercell interactions. Its expression is enhanced in tissue injury and remodeling, and in degenerative diseases such as Alzheimer's disease.

clusterin

(klus'te-rin) [ cluster + -in],

CLU.

A multifunctional cell-protective glycoprotein (molecular weight 75-80 kDa) found in many tissues. High levels of CLU are found in cells undergoing apoptosis. Synonym: apolipoprotein J
References in periodicals archive ?
living HIV on One of the compounds identified - a protein called clusterin - has been linked to neurodegenerative diseases including Alzheimer's disease, according to the research published in journal Neuroendocrinology Letters.
About Custirsen Custirsen is a highly specific clusterin inhibitor designed to improve survival in patients with advanced cancer by disabling a fundamental cellular repair mechanism used by tumor cells.
has unveiled results from further exploratory analyses of the Phase 3 SYNERGY trial showing that custirsen treatment considerably reduced serum clusterin (sCLU) levels from baseline in males with metastatic castrate-resistant prostate cancer (mCRPC).
Clusterin confers resistance to TNF-alpha-induced apoptosis in breast cancer cells through NF-kappaB activation and Bcl-2 overexpression.
Upregulation of clusterin in prostate and DNA damage in spermatozoa from bisphenol A-treated rats and formation of DNA adducts in cultured human prostatic cells.
Immunohhistochemical Marker Cell type CD45 CD21 CD23 CD35 SI00 CDla Langerin Fascin LCH LC (+) (-) (-) (-) (+) (+) (+) only + IDC (+) (-) (-) (-) (+) (-) (-) (+) Macrophage or (+) (-) (-) (-) (+/-) (-) (-) (+/-) histiocyte l/DDC (+) (-) (-) (-) (-/+) (-) (-) (+) pDC (-) (-) (-) (-) (-) (-) (-) (-) FDC (-) (+) (+) (+) (+/-) (-) (-) (+) FRC (+) (-) (-) (-) (-) (-) (-) Cell type Clusterin CD68 CD123 CD163 CD4 FXIIIa TCLI LC (-) (+) (-) (-) (+) (-) (-) IDC (-/+) (+/-) (-) (-) (+) (-) y Macrophage or (-) (+) (-) (+) (+) (-) (-) histiocyte l/DDC (-) (+) (-) (-) (+/-) (+) (-) pDC (-) (+) (+.
Researchers at King's College London believe that by identifying clusterin as a trigger for Alzheimer's they have taken a vital step towards developing treatments to stop the devastating disease.
Urinary clusterin, cystatin C, [beta]2-microglobulin and total protein as markers to detect drug-induced kidney injury.
A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2′-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer.
Jo et al [66] reported the interplay between IGF-1 and cancer cell-derived clusterin durin metastasis, therefore demonstrating the level of complexity of IGF-I related activity with reference to cellular responses.
91) Fascin and clusterin can be expressed in both ALCL and HL92; however, clusterin expression in HL usually shows a membranous pattern rather than the punctate, cytoplasmic pattern seen in ALCL.
Elevated plasma levels of a protein called clusterin appear to correlate with the degree of brain atrophy, the severity of symptoms, and the speed of the clinical progression of Alzheimer's disease, a report shows.