clusterin


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clusterin

 [klus´ter-in]
a multifunctional glycoprotein with roles in the metabolism and transport of lipids and membrane fragments, secretion of hormones, reproductive biology, inhibition of assembly of the membrane attack complex of complement activation, programmed cell death, and modulation of intercell interactions; its expression is enhanced in tissue injury and remodeling as well as in degenerative diseases such as alzheimer's disease.

clusterin

(klŭs'tĕr-in),
Heterodimeric highly conserved secreted glycoprotein, which is expressed in a wide variety of tissues and found in all human fluids; implicated in physiologic processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis.
Synonym(s): apolipoprotein J

clusterin

[klus′terin]
a multifunctional glycoprotein with roles in the metabolism and transport of lipids and membrane fragments, secretion of hormones, reproductive biology, inhibition of assembly of the membrane attack complex of complement activation, programmed cell death, and modulation of intercell interactions. Its expression is enhanced in tissue injury and remodeling, and in degenerative diseases such as Alzheimer's disease.

clusterin

(klus'te-rin) [ cluster + -in],

CLU.

A multifunctional cell-protective glycoprotein (molecular weight 75-80 kDa) found in many tissues. High levels of CLU are found in cells undergoing apoptosis. Synonym: apolipoprotein J
References in periodicals archive ?
34] In addition, several other genes involved in cholesterol metabolism have been reported to be associated with AD including adenosine triphosphate-binding cassette subfamily A member 7,[46] clusterin, and sortilin-related receptor (SORL1).
Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney.
Clusterin (complement lysis inhibitor) forms a high density lipoprotein complex with apolipoprotein A-I in human plasma.
136) A few studies have demonstrated a canalicular clusterin staining pattern in 54% to 75% of HCCs.
Yapilan calismalarda, hucrelerin apoptotik uyaranlara karsi stabilizasyonunda rol oynayan HSP27 ve clusterin saperon proteinlerin asiri ifadelenmesinin PK ile baglantili oldugu rapor edilmistir (34,35,36,37,38,39,40).
These proteins are APOE, clusterin (CLUS), [alpha]-L-fucosidase (FUCO), galectin-3 binding protein (LG3BP), and phosphatidylethanolamine binding protein 1 (PEBP1).
Lentivirus-mediated shRNA interference of clusterin blocks proliferation, motility, invasion and cell cyle in the ovarian cancer cells.
The degree of oxidation of clusterin was upregulated in MS patients as compared to the healthy controls [1].
living HIV on One of the compounds identified - a protein called clusterin - has been linked to neurodegenerative diseases including Alzheimer's disease, according to the research published in journal Neuroendocrinology Letters.
has unveiled results from further exploratory analyses of the Phase 3 SYNERGY trial showing that custirsen treatment considerably reduced serum clusterin (sCLU) levels from baseline in males with metastatic castrate-resistant prostate cancer (mCRPC).
Custirsen is an experimental drug that is designed to block the production of the protein clusterin, which may play a fundamental role in cancer cell survival and treatment resistance.
Clusterin confers resistance to TNF-alpha-induced apoptosis in breast cancer cells through NF-kappaB activation and Bcl-2 overexpression.