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clozapine

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clozapine /clo·za·pine/ (klo´zah-pen) a sedative and antipsychotic agent; used in the treatment of schizophrenia.
clo·za·pine (klz-pn, -pn)
n.
An antipsychotic drug used as a sedative and in the treatment of schizophrenia.
clozapine (klō´zpēn´),
n brand name: Clozaril;
drug class: antipsychotic, atypical;
action: interferes with binding of dopamine at D1 and D2 receptors; acts as adrenergic, cholinergic, histaminergic, and serotonergic antagonist;
uses: management of psychotic symptoms in schizophrenic patients for whom other antipsychotics have failed.
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7), we said that St John's wort may increase the activity of protease inhibitors, digitalis, statins, warfarin, chemotherapy drugs, oral contraceptives, tricyclic antidepressants, and clozapine, olanzapine, and theophylline.
Correction by Nutrition Action Healthletter
In some cases, the newer, atypical antipsychotic drugs such as clozapine or olanzapine may help relieve severe or refractory symptoms of bipolar disorder and prevent recurrences of mania.
Going to Extremes: Bipolar Disorder by Pamphlet by: National Institute of Mental Health
The psychoactive drug clozapine, for example, causes dangerous blood-clotting disorders in about 5% of patients.
Arrays Cast Toxicology in a New Light by Lauerman, John F. / Environmental Health Perspectives
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