clotting time

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Related to clotting time: coagulation time, Bleeding time


a measure of duration. See under adjectives for specific times, such as bleeding time.
activated partial thromboplastin time (APTT, aPTT) the period required for clot formation in recalcified blood plasma after contact activation and the addition of platelet substitutes such as brain cephalins or similar phospholipids; used to assess the coagulation pathways. A prolonged aPTT can indicate a deficiency of any of various coagulation factors, including factors XII, XI, IX, VIII, X, V, and II, and fibrinogen.
AEC minimal response time the shortest duration at which x-ray exposure can be terminated by automatic exposure control.
atrioventricular sequential time a fixed nonprogrammable interval that extends from the atrial stimulus to the ventricular stimulus.
bleeding time the time required for a standardized wound to stop bleeding; used as a test for platelet disorders; see also bleeding time.
circulation time the time required for blood to flow between two given points; see also circulation time.
clotting time (coagulation time) the time required for blood to clot in a glass tube; see also clotting.
cold ischemia time the time between the placement of a traumatically amputated body part in ice and the time of surgical replantation.
inertia time the time required to overcome the inertia of a muscle after reception of a stimulus.
ischemia time the total time between traumatic amputation of a limb or portion of a limb and its surgical reimplantation; it is the sum of warm and cold ischemia times.
minimal response time in radiology, the shortest possible exposure time for an x-ray film to be exposed automatically.
one-stage prothrombin time prothrombin time.
prothrombin time see prothrombin time.
real time a term used to describe a recording device that shows events simultaneously to their occurrence.
thrombin time the time required for plasma fibrinogen to form thrombin; see also thrombin time.
warm ischemia time the time interval between traumatic amputation of a limb or part and its placement on ice.

co·ag·u·la·tion time

temporal duration required for blood to coagulate.
Synonym(s): clotting time

clotting time

Etymology: AS, clott
the time required for blood to form a clot, tested by collecting 4 mL of blood in a glass tube and examining it for clot formation. The first appearance of a clot is noted and timed. The normal coagulation time in glass tubes is 5 to 15 minutes. This simple test has been used to diagnose hemophilia, but it does not detect mild coagulation disorders. Its chief application is in monitoring anticoagulant therapy. It is rarely used in clinical practice. Also called coagulation time. Compare bleeding time.

coagulation time

; clotting time time taken for liquid blood to clot (see INR)

co·ag·u·la·tion time

(kō-ag'yū-lā'shŭn tīm)
Temporal duration required for blood to coagulate.
Synonym(s): clotting time.


the formation of a jellylike substance over the ends or within the walls of a blood vessel, with resultant stoppage of the blood flow. Clotting is one of the natural defense mechanisms of the body when injury occurs. A clot will usually form within 5 minutes after a blood vessel wall has been damaged. The clotting mechanism is triggered by the platelets, which disintegrate as they pass over rough places in the injured surface. As they disintegrate they release serotonin and thromboplastin. Serotonin causes constriction of the blood vessels and reduction of local blood pressure. Thromboplastin unites with calcium ions and other substances which promote the formation of fibrin. When examined under a microscope, a clot consists of a mesh of fine threads of fibrin in which are embedded erythrocytes and leukocytes, small amounts of fluid (serum), and platelets.

clotting defects
clotting factors
a series of plasma proteins which are related through a complex cascade of enzyme-catalyzed reactions involving the sequential cleavage of large protein molecules to produce peptides, each of which converts an inactive zymogen precursor (factor II) into an active enzyme (Iia) leading to the formation of a fibrin clot. They are designated by Roman numerals, and an additional 'a' to indicate the activated state. They are: factor I (fibrinogen), factor II (prothrombin), factor III (tissue thromboplastin), factor IV (calcium), factor V (proaccelerin), factor VI (no longer considered active in hemostasis), factor VII (proconvertin), factor VIII (antihemophilic factor), factor IX (plasma thromboplastin component; Christmas factor), factor X (stuart factor), factor XI (plasma thromboplastin antecedent), factor XII (hageman factor), factor XIII (fibrin stabilizing factor).
clotting time
the time required for blood to clot in a glass tube; a measure of the intrinsic system of coagulation. In the Lee-White method, blood in test tubes is maintained at a constant temperature and examined regularly until clotting occurs; the test can be also be performed in capillary tubes. Called also coagulation time. Less sensitive and now less often used than the activated coagulation time.
tissue clotting factor
clotting factor III; tissue thromboplastin.

Patient discussion about clotting time

Q. i have a small blood clot above my heart that bother me dome times. i also have had bypass sugary this past march, my heart doctor says it has nothing to do with my heart, has anyone else had this problem and if so what or how have you dealt with it?

A. the heart doctor says it is so small that right now they cannot do any thing about ,but are trying to cure it with meds but so far it is not working

More discussions about clotting time
References in periodicals archive ?
Whole blood activated clotting time in infants during extracorporeal membrane oxygenation.
9]/l) 367,8 [+ or -] 10,4 Platelet adhesion (%) 33,8 [+ or -] 1,7 Platelet aggregation (s) 22,0 [+ or -] 0,7 Clotting time Lee-White (min) in 5,1 [+ or -] 0,53 non-siliconized tube in siliconized tube 7,1 [+ or -] 0,7 Starting clotting (s) 483,8 [+ or -] 21,7 Duration of blood clotting (s) 253,0 [+ or -] 2,8 Closing clotting (s) 720,1 [+ or -] 21,9 Blood viscosity (unit of activity) 2,6 [+ or -] 0,5 The density of blood (units of activity) 0,02 [+ or -] 0,5 Plasma recalcification time (s) 120,0 [+ or -] 2,3 Plasma kaolin time (s) 89,3 [+ or -] 1,0 Kaolin cephalin time (s) 39,3 [+ or -] 1,2 ACT (s) for 6 min.
Similarly, vital parameters, bleeding time and clotting time were measured at baseline and after 4 h of drug administration on day one and day 10.
Point-of-care ecarin clotting time versus activated clotting time in correlation with bivalirudin concentration.
Most cardiac surgical units are not equipped with an ecarin clotting time point-of-care analyser (specific for bivalirudin) (11), although use of plasma modified ACT has been described (12).
1, maximum deviation shown) but are within current practice: (a) collection of blood into SST II Plus or plain tubes, (b) 2-h clotting time, (c) centrifugation at 23508, (d) 48-h storage of serum, and (e) use of Roche Modular II.
The PFA-100 device measures the clotting time of a blood sample that is pumped through a collagen-coated membrane, a test design that mimics the behavior of circulating blood.
Blood clotting times have been reported to double in patients taking warfarin and garlic supplements.
Though both the wine and cocoa significantly delayed the blood's clotting time, only the cocoa protected blood platelets from fragmentation.
T2Hemostasis, which utilizes the company's proprietary T2MR detector, is able to monitor several key hemostasis measurements, including clotting time, platelet activity, fibrinolysis and hematocrit, on a single assay in minutes," said John McDonough, CEO, T2 Biosystems.
Thus, clotting time of the whole blood, recalcification time, activated recalcification time of the common and thrombocytes-free plasma have the biggest value in spring and the least one--in autumn.