clotting


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Related to clotting: clotting time, Clotting factors, Clotting cascade

clotting

 [klot´ing]
the formation of a jellylike substance over the ends or within the walls of a blood vessel, with resultant stoppage of the blood flow; called also coagulation.

Clotting is one of the natural defense mechanisms of the body when injury occurs. A clot will usually form within 5 minutes after a blood vessel wall has been damaged. The exact process of clotting is not known; however, it is believed that the mechanism is initiated by the platelets, which adhere and aggregate as they come in contact with the injured surface. As they aggregate they release serotonin and other substances from their dense granules. Serotonin causes constriction of the blood vessels and reduction of blood flow. Thromboplastin unites with calcium ions and other substances that promote the formation of fibrin. When examined under a microscope, a clot consists of a mesh of fine threads of fibrin in which are embedded erythrocytes and leukocytes and small amounts of fluid (serum).

Twelve factors essential to normal blood clotting have been described; see coagulation factors. At least four platelet factors also exist that have a part in clotting.

It is possible for a clot to form within a blood vessel if the inner wall of the vessel has been roughened by injury or disease. Clots may form in conditions such as arteriosclerosis, varicose veins, and thrombophlebitis. An internal clot that remains at the place where it forms is called a thrombus; the general condition is called thrombosis. If the clot (or pieces of it) breaks loose and flows through the blood vessels, it is called an embolus, and the condition is called embolism.

Clotting of the blood can be hastened by contact with injured tissue, by warming, by adding such coagulants as calcium, or by combination with thromboplastin and thrombin. The process can be retarded by cooling, by dilution, by adding oxalates and citrates, or by administration of substances such as heparin and dicumarol, called anticoagulants.
The clotting process.

clotting

/clot·ting/ (klot´ing) coagulation (1).

clotting

clot·ting

(kloting)
Process of coagulation; the transformation of blood from a liquid into a semisolid mass.

clotting

See BLOOD CLOTTING.

clotting

the formation of a jellylike substance over the ends or within the walls of a blood vessel, with resultant stoppage of the blood flow. Clotting is one of the natural defense mechanisms of the body when injury occurs. A clot will usually form within 5 minutes after a blood vessel wall has been damaged. The clotting mechanism is triggered by the platelets, which disintegrate as they pass over rough places in the injured surface. As they disintegrate they release serotonin and thromboplastin. Serotonin causes constriction of the blood vessels and reduction of local blood pressure. Thromboplastin unites with calcium ions and other substances which promote the formation of fibrin. When examined under a microscope, a clot consists of a mesh of fine threads of fibrin in which are embedded erythrocytes and leukocytes, small amounts of fluid (serum), and platelets.

clotting defects
clotting factors
a series of plasma proteins which are related through a complex cascade of enzyme-catalyzed reactions involving the sequential cleavage of large protein molecules to produce peptides, each of which converts an inactive zymogen precursor (factor II) into an active enzyme (Iia) leading to the formation of a fibrin clot. They are designated by Roman numerals, and an additional 'a' to indicate the activated state. They are: factor I (fibrinogen), factor II (prothrombin), factor III (tissue thromboplastin), factor IV (calcium), factor V (proaccelerin), factor VI (no longer considered active in hemostasis), factor VII (proconvertin), factor VIII (antihemophilic factor), factor IX (plasma thromboplastin component; Christmas factor), factor X (stuart factor), factor XI (plasma thromboplastin antecedent), factor XII (hageman factor), factor XIII (fibrin stabilizing factor).
clotting time
the time required for blood to clot in a glass tube; a measure of the intrinsic system of coagulation. In the Lee-White method, blood in test tubes is maintained at a constant temperature and examined regularly until clotting occurs; the test can be also be performed in capillary tubes. Called also coagulation time. Less sensitive and now less often used than the activated coagulation time.
tissue clotting factor
clotting factor III; tissue thromboplastin.

Patient discussion about clotting

Q. What causes blood clots? My father had a heart attack which was caused by a blood clot. Am I at risk for developing blood clots too? How do I prevent it from happening?

A. I found a website that checks your risks for inheriting your family's illness, including blood clots. They have a test you can do which is called "Free Risk Assessment for Thrombophilia":
http://www.dnadirect.com/patients/tests/blood_clotting/more_about/GH_Thr_Risk.jsp

Q. How can I prevent blood clots? I am 45 years old and am supposed to go on a business trip overseas. The flight itself is 12 hours long and then I have to continue traveling by bus. Could this cause me to have blood clots? If so, how can I prevent it?

A. Always walk as much as you can on the plane. Also, rotate your ankels in circles. Sometimes try to use your ankels and make the alphabet with them. Have fun..

Q. very dark blood clots @ first sight of period? At first sight of period, instead of normal rosy spotting it's brownish spotting followed by small clots.

A. totally agree with hottie, most likely that will be in normal range of variation. unless you feel some unusual pain, then you need to find medical advice. but it is also suggested for you to go to your ob-gyn doctor for a regular checkup anyway.
stay healthy always..

More discussions about clotting
References in periodicals archive ?
NBCA works on behalf of people who may be susceptible to blood clots, including, but not limited to, people with clotting disorders, atrial fibrillation, cancer, traumatic injury, and risks related to surgery, lengthy immobility, child birth and birth control.
A traveler developing a blood clot may need to be tested for inherited clotting disorders and other conditions.
For decades, people have known that blood-clotting proteins have to bind to a cell membrane in order for the clotting reaction to happen," said James Morrissey.
Predicting risks associated with these transient alterations in inflammatory and clotting factors will require more research and discussion.
Drew Fromkin, President and CEO, explained, "Warfarin is commonly prescribed for the treatment and prevention of blood clotting, but dosing is a challenging process requiring frequent monitoring to achieve a stable maintenance dose.
The formation of inhibitors or antibodies to hemophilia clotting factor is a serious condition that may affects up to 30% of people living with hemophilia at some time during the course of their lives.
Contraceptive drugs contain hormones known to promote clotting, the researchers note.
The scientists at Okayama University concluded: "The clotting properties (partial thromboplastin time, prothrombin time and the amount of fibrinogen) for plasma in contact with samples of hydroxyapatite and plasma which did not have any contact with hydroxyapatite were the same.
The new coating material staves off clotting because its copper ions catalyze the production of nitric oxide in the blood, says Mark Meyerhoff of the University of Michigan in Ann Arbor.
reported an increased susceptibility to clotting in rabbits that had inhaled carbon nanospheres.
Unlike blood- thinning drugs, which prevent future clotting but leave the existing clots in place, catheter-directed thrombolysis delivers clot-busting drugs directly into the clots, causing them to dissolve.
The anticoagulant effects of MC-45308 were evaluated with a series of recognized lab tests used to monitor the clotting ability of whole blood.