clotrimazole


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clotrimazole

 [klo-trim´ah-zōl]
a synthetic broad-spectrum antifungal agent applied topically to the skin in the treatment of candidiasis and various forms of tinea, and administered intravaginally in the treatment of vulvovaginal candidiasis and orally in the prevention and treatment of candidiasis of the mouth and throat.

clotrimazole

/clo·trim·a·zole/ (klo-trim´ah-zōl) an imidazole derivative used as a broad-spectrum antifungal agent.

clotrimazole

(klō-trĭm′ə-zōl′)
n.
A broad-spectrum antifungal drug, C22H17ClN2, used topically to treat a variety of superficial fungal infections, including candidiasis and ringworm.

clotrimazole

[klōtrim′əzōl]
a broad-spectrum antifungal agent of the imidazole group used in topical applications to treat fungal and yeast infections, including tinea pedis, tinea cruris, tinea corporis, tinea versicolor, oral candidiasis, and vaginal candidiasis.
indications It is prescribed in the treatment of superficial fungal infections and candidal vulvovaginitis. Oral troches are used for prophylaxis against fungal infections in neutropenic patients.
contraindications Known hypersensitivity to this drug prohibits its use. It is not prescribed for ophthalmic use; contact with eyes should be avoided.
adverse effects The most serious adverse reactions are severe hypersensitivity reactions of the skin. The use of oral troches often causes liver enzyme abnormalities.

clotrimazole

Infectious disease An antifungal imidazole used topically for candidiasis Adverse effects Nausea, dizziness, diarrhea, changed LFTs

clotrimazole

A drug effective against a wide range of fungi. It is used in the form of creams, for local application. Brand names are Canesten and Masnoderm. Formulated with BETAMETHASONE it is marketed under the brand name Lotriderm.

clotrimazole

; Canesten topical broad-spectrum, imidazole antifungal agent (1% cream) used to treat tinea pedis and candidal infections (Table A13)

antifungal agent 

Any substance which destroys or prevents the growth of fungi. It is one of the antibiotic groups. There are several classes of antifungal drugs: Polyenes, which cause an increase in fungal cell wall permeability leading to its death. Examples: amphotericin B, natamycin, nystatin. Azoles, which act either by inhibiting the synthesis of ergosterol, a component of fungal cell wall or by causing direct wall damage. Examples: clotrimazole, econazole, fluconazole, itraconazole, ketoconazole, miconazole. Pyrimidines, which interfere with the normal function of fungal cells. Example: flucytosine. Syn antimycotic agent.

clotrimazole (klōtrim´əzōl´),

n brand names: Lotrimin, Canesten, Gyne-Lotrimin, Mycelex-7, Mycelex Troches;
drug class: inidazole antiinfective;
action: interferes with fungal DNA replication;
uses: tinea pedis, tinea cruris, tinea corporis, tinea vesicolor, and
C. albicans infection of the oral cavity, pharynx, vulva, and vagina.

clotrimazole

a synthetic imidazole derivative with antifungal activity, similar to ketoconazole; applied topically in the treatment of diseases caused by dermatophytes and yeasts.
References in periodicals archive ?
19) According to Stern et al and Jackman et al, clotrimazole is an effective antifungal agent against most yeasts and fungi, and nystatin has the widest spectrum of activity among the antifungals.
Lorus' research programme involved extensive evaluation of the clotrimazole analogue series in preclinical models and resulted in the selection of CYC381 as the lead candidate.
Roland: I use the ciprofloxacin, clotrimazole, and dexamethasone powder that I mentioned earlier.
Certain statements in this release are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding the Company's clotrimazole and betamethasone dipropionate lotion.
Murphy, Chairman and CEO, said, "We are very pleased with the preliminary findings which demonstrate that with Bentley's proprietary drug delivery technology (CPE-215(R)) this clotrimazole lacquer formulation is able to treat this very frustrating disease.
In addition, we have been an innovator in this category with the FDA approval of Taro's New Drug Application ("NDA") for our Clotrimazole 3-Day Vaginal Cream product.
Competing in a $134 million feminine hygiene market, M-Zole 3 is now available and will complement Alpharma USPD's existing line of women's health products, which include Clotrimazole Vaginal Cream USP 1%, Triple Sulfa Vaginal Cream and Miconazole Nitrate Cream and Suppositories.
The study, utilizing a clotrimazole lacquer formulation containing Bentley's proprietary drug delivery technology (CPE-215(R)), revealed that of 18 patients who completed the study, three months following treatment 16 showed improvement over their baseline condition, with five of those showing a complete cure (three or more millimeters of healthy nail growth and a negative culture for the fungus) and an additional ten showing a mycological cure (less than three millimeters of healthy nail growth and a negative culture for the fungus).
Halperin, Associate Professor of Medicine at Harvard Medical School in the Laboratory for Membrane Transport, includes the anti-cancer applications to a large number of new chemical entities (NCEs) which are related to the anti-fungal agent, clotrimazole, and the anti-cancer applications of clotrimazole itself.
Tenders are invited for Ointment Clotrimazole And Beclomethasone With Neomycin In 15Gm Tube
The technology which is being licensed by the new subsidiary includes the anti-cancer applications to a large number of new chemical entities (NCEs) which are related to the anti-fungal agent, clotrimazole, and the anti-cancer applications of clotrimazole itself.