clopidogrel


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Related to clopidogrel: clopidogrel bisulfate

clopidogrel

 [klo-pid´ah-grel]
an inhibitor of platelet aggregation, used in the form of the bisulfate salt to prevent formation of thrombi and prevent myocardial infarction, stroke, and vascular death in patients with atherosclerosis; administered orally.

clopidogrel

/clo·pid·o·grel/ (klo-pid´o-grel) a platelet inhibitor used as an antithrombotic for the prevention of myocardial infarction, stroke, and vascular death in patients with atherosclerosis; used as the bisulfate salt.

clopidogrel

(klō-pĭd′ə-grĕl′)
n.
A drug, C16H16ClNO2S, given in the form of its bisulfate, that inhibits platelet aggregation and is used in the treatment of patients with peripheral arterial disease, certain forms of angina, or a recent history of heart attack or stroke.

clopidogrel

a platelet aggregation inhibitor.
indications It is used to reduce the risk of stroke and myocardial infarction in high-risk patients.
contraindications Known hypersensitivity, active bleeding, and increased risk for bleeding (e.g., peptic ulcers) prohibits its use.
adverse effects Intracranial hemorrhage is a potential life-threatening side effect. Other adverse effects include rash, pruritus, nausea, vomiting, diarrhea, epistaxis, purpura, edema, hypertension, chest pain, headache, dizziness, musculoskeletal pain, upper respiratory tract infection, bronchitis, urinary tract infection, and hypercholesterolemia.

clopidogrel

Plavix® Cardiology An antiplatelet agent that ↓ the risk of ischemic stroke, MI, and vascular death in Pts with prior cardiovascular disease Contraindications Active bleeding–eg, PUD, intracranial hemorrhage, or Pts at risk for bleeding due to trauma, surgery or other drug therapy Adverse events Dyspepsia, purpura, diarrhea, rash, intracranial hemorrhage, neutropenia. See CAPRIE. Cf Aspirin.

clopidogrel

A drug that acts mainly by inhibiting the ADP-mediated platelet aggregation pathway and has been shown to reduce mortality in patients with acute myocardial infarction. It usefully potentiates the action of aspirin. A brand name is Plavix.

antiplatelet therapy

agents that reduce platelet aggregation and inhibit arterial thrombus formation in an area of the circulation where other anticoagulants have reduced effect; e.g. low-dose aspirin (75 mg daily), clopidogrel (± low-dose aspirin), dipyridamole (used to prevent thromboembolism in patients with prosthetic heart valves), abciximab, eptifibatide and tirofiban
References in periodicals archive ?
He was started on clopidogrel (300 mg loading followed by 75 mg daily) for at least 12 months.
A sub-study of the PLATO trial has also confirmed that patients treated with clopidogrel, who have a genetic variant, have a slightly higher risk in the first month following a heart attack.
versus 15 percent in patients with diabetes treated with clopidogrel.
Surgeons make more of a big deal about clopidogrel than they need to," he added.
Dr Marshall used estimates of cost and effectiveness for aspirin, antihypertensive (blood pressure) drugs, simvastatin and clopidogrel to calculate the cost of each coronary event prevented in a patient with a ten per cent risk of heart disease.
The MATCH study compared aspirin 75 mg/day with placebo in 7599 high-risk patients with recent ischemic CVA or transient ischemic attack and at least one additional vascular risk factor; patients were already receiving clopidogrel 75 mg/day for up to 18 months (4).
For international and China market analysis, the report analyzes Clopidogrel Bisulfate Market in China and other countries or regions (such as US, Europe, Japan, etc) by presenting research on global products of different types and applications, developments and trends of market, technology, competitive landscape, and leading suppliers' and countries' 2010-2015 capacity, production, cost, price, profit, production value, and gross margin.
It was also seen that the event rate was much higher in the diabetic than in the nondiabetic subgroup despite more intense antiplatelet therapy with the adjunctive use of clopidogrel (Yusuf et al.
Initial studies suggested that this assay could identify patients at increased risk for thrombotic events after PCI while on clopidogrel therapy (1).
Then all patients were randomized into two groups and treated for three months with aspirin alone or aspirin plus clopidogrel, which is marketed as Plavix.