clopidogrel


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Related to clopidogrel: clopidogrel bisulfate

clopidogrel

 [klo-pid´ah-grel]
an inhibitor of platelet aggregation, used in the form of the bisulfate salt to prevent formation of thrombi and prevent myocardial infarction, stroke, and vascular death in patients with atherosclerosis; administered orally.

clopidogrel

/clo·pid·o·grel/ (klo-pid´o-grel) a platelet inhibitor used as an antithrombotic for the prevention of myocardial infarction, stroke, and vascular death in patients with atherosclerosis; used as the bisulfate salt.

clopidogrel

(klō-pĭd′ə-grĕl′)
n.
A drug, C16H16ClNO2S, given in the form of its bisulfate, that inhibits platelet aggregation and is used in the treatment of patients with peripheral arterial disease, certain forms of angina, or a recent history of heart attack or stroke.

clopidogrel

a platelet aggregation inhibitor.
indications It is used to reduce the risk of stroke and myocardial infarction in high-risk patients.
contraindications Known hypersensitivity, active bleeding, and increased risk for bleeding (e.g., peptic ulcers) prohibits its use.
adverse effects Intracranial hemorrhage is a potential life-threatening side effect. Other adverse effects include rash, pruritus, nausea, vomiting, diarrhea, epistaxis, purpura, edema, hypertension, chest pain, headache, dizziness, musculoskeletal pain, upper respiratory tract infection, bronchitis, urinary tract infection, and hypercholesterolemia.

clopidogrel

Plavix® Cardiology An antiplatelet agent that ↓ the risk of ischemic stroke, MI, and vascular death in Pts with prior cardiovascular disease Contraindications Active bleeding–eg, PUD, intracranial hemorrhage, or Pts at risk for bleeding due to trauma, surgery or other drug therapy Adverse events Dyspepsia, purpura, diarrhea, rash, intracranial hemorrhage, neutropenia. See CAPRIE. Cf Aspirin.

clopidogrel

A drug that acts mainly by inhibiting the ADP-mediated platelet aggregation pathway and has been shown to reduce mortality in patients with acute myocardial infarction. It usefully potentiates the action of aspirin. A brand name is Plavix.
References in periodicals archive ?
Clopidogrel has been available in the United States since 1997 and has been studied in a wide variety of thrombotic CVDs.
The TRILOGY-ACS study enrolled 9326 ACS patients treated medically with aspirin and either clopidogrel or prasugrel (4).
He said that anybody with a transient ischemic attack or minor stroke will get clopidogrel plus aspirin.
Thus, this trial was aimed to compare the relative efficacy and safety of aspirin plus extended-release dipyridamole with that of clopidogrel among patients who had a recent ischaemic stroke.
While the study did not demonstrate prasugrel was superior to clopidogrel in these patients, TRILOGY ACS provided some additional observations in this previously understudied population.
were among the companies gaining FDA approval for 300-mg clopidogrel.
Eric Bates, professor of internal medicine at the University of Michigan, Ann Arbor, said that it will be interesting to follow pricing trends over the next 12 years and to see how the availability of generic clopidogrel affects the market shares of the new entrants to the anti-platelet field, prasugrel (Effient) and ticagrelor (Brilinta).
The ANDAs for Clopidogrel Tablets USP, 75 mg & 300 mg are approved by the US Food & Drug Administration (USFDA).
Additionally, the company was the first to have filed a substantially complete ANDA containing a Paragraph IV certification to the FDA for Clopidogrel Tablets, 300 mg, and was awarded 180 days of marketing exclusivity for this strength.
Se observo una diferencia en la respuesta al clopidogrel interindividual estadisticamente significativa en algunos pacientes, presentando "resistencia" a la terapia antiplaquetaria.