In contrast, the presence of a dominating DNA fragment indicative of clonality
is illustrated by the patient samples in lanes 2, 3, and 4, which exhibit one or more densely stained bands in the 150- to 250-bp region and compare favorably with the positive controls in lanes 7 and 8.
testing: interpretation and limitations.
We used a gold standard multiplex PCR protocol provided by European Biomedicine and Health (BIOMED-2) Concerted Action Project BMH4-CT98-3936 for improvement of diagnosis and analysis of clonality
gene rearrangement in lymphoma malignancies.
These results suggest that clonality
is an important trait for sexual reproduction to C.
However, additional sampling would seem unlikely to alter our basic conclusions, particularly with regard to the level of MLG diversity across the continental range and the extent of clonality
within and among localities.
seems to be an important feature of the central-south populations of P.
Optimization of PCR amplification for B-and T-cell clonality
analysis on formalin-fixed and paraffin-embedded samples.
leprae might encode unique characteristics that could elicit the Lucio reaction is attractive and seems plausible, although highly speculative and challenging to prove, since genetic clonality
and the absence of overt toxic affects in animal models seem to be major characteristics of M.
Safety will be determined by clinical and laboratory observation and grading of adverse events, analysis of T cell repertoire clonality
, and evaluation of HIV isolates for evidence of vector recombination.
studies for the presence of clonal IgH or Ig Kappa gene rearrangement would be useful in differentiating it from a plasmacytoma.
Nevertheless, determination of clonality
is not usually necessary to establish a diagnosis of large-cell lymphoma while it is frequently necessary for lymphoproliferative disorders in which the cells are not morphologically abnormal such as chronic lymphocytic leukemia.
Sydes, MA and Peakall, R: Extensive clonality
in the endangered shrub Haloragodendron lucasii (Haloragaceae) revealed by allozymes and RAPDs.