clonal selection theory


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Related to clonal selection theory: clonal selection theory of immunity

clo·nal se·lec·tion the·o·ry

a theory which states that each lymphocyte has membrane-bound immunoglobulin receptors specific for a particular antigen and after the receptor is engaged, proliferation of the cell occurs such that a clone of antibody-producing cells (plasma cell) is produced.

clonal selection theory

clo·nal se·lec·tion the·or·y

(klō'năl sĕ-lek'shŭn thē'ŏr-ē)
A theory that states that each lymphocyte has membrane-bound immunoglobulin receptors specific for a particular antigen and after the receptor is engaged, proliferation of the cell occurs such that a clone of antibody producing cells (plasma cell) is produced.

clonal selection theory

a onetime theory now accepted as an established part of immunological dogma. Each lymphocyte during its development is committed to respond to one antigenic determinant. Accordingly each lymphocyte has a single type of antigen-specific receptor on its surface. Following contact with antigen, a single lymphocyte expands to form a clone of cells.