clonal expansion

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Related to clonal expansion: Clonal selection

clo·nal ex·pan·sion

production of daughter cells all arising originally from a single cell. In a clonal expansion of lymphocytes, all progeny share the same antigen specificity.


referring to a clone.

clonal expansion
occurs, for example, when B cells, under the influence of T cell interleukins, differentiate into two separate populations and, after several transformations produce sensitized B lymphocytes and plasma cells.
References in periodicals archive ?
An inhibitory effect of resveratrol in the mitotic clonal expansion and insulin signaling pathway in the early phase of adipogenesis.
Two-stage clonal expansion models of cancer that account explicitly for mutation of normal cells to initiated cells, clonal expansion of initiated cells, and mutation of initiated cells to fully malignant cells (Moolgavkar et al.
DNA synthesis and mitotic clonal expansion is not a required step for 3T3-L1 preadipocyte differentiation into adipocytes.
Marginal-zone B cells in the human lymph node and spleen show somatic hypermutations and display clonal expansion.
These clades are thought to be basal to the highly fit clonal expansion on these continents.
Such a vaccination has already demonstrated increased in-vivo clonal expansion and maintenance of adoptively transferred tumor-antigen specific cytotoxic lymphocytes in preclinical models.
We conclude that the relatively limited variation in clonal variants (STs) and ESBL genotypes is a consequence of recent introduction from connecting areas, such as Canada, possibly directly by bird migration or human activities, of a few resistant clones, followed by a local clonal expansion.
21] The detection of EBV genome in both components of our cases further supports the intimate relationship between the UCNP and adenocarcinoma and is compatible with the assumption that both components arose from the clonal expansion of a single EBV-infected cell.
Outbreak of W135 meningococcal disease in 2000: not emergence of a new W135 strain but clonal expansion within the electrophoretic type-37 complex.
Serogroup W135 strains are widely distributed worldwide; the emergence of these strains during the 2000s corresponded to a clonal expansion of 1 clone within the ST11 complex (7).
Rapid clonal expansion, persistence and clonal replacement of meningococcal isolates in a 2008 university student cohort.