clonal expansion


Also found in: Dictionary, Thesaurus, Legal, Financial, Encyclopedia.
Related to clonal expansion: Clonal selection

clo·nal ex·pan·sion

production of daughter cells all arising originally from a single cell. In a clonal expansion of lymphocytes, all progeny share the same antigen specificity.

clonal

referring to a clone.

clonal expansion
occurs, for example, when B cells, under the influence of T cell interleukins, differentiate into two separate populations and, after several transformations produce sensitized B lymphocytes and plasma cells.
References in periodicals archive ?
Treatment with compounds inducing differentiation of 3T3-L1 preadipocytes leads to mitotic clonal expansion prior to the expression of PPAR[gamma], a key adipogenic transcription factor.
Clonal expansion of the mutations characterized in each somatic tissue and in caudal sperm.
A third emerging application of tracking clonal expansion is in the context of autoimmune diseases, where research is attempting to identify particular V - (D) - J recombinants associated with autoimmune diseases with the plan of monitoring their levels in response to therapeutic options.
2010) Bcl11b heterozygosity promotes clonal expansion and differentiation arrest of thymocytes in [gamma]-irradiated mice.
Although implementation of BBDR models for low-dose risk estimation have been limited mainly to cancer modeled using a two-stage clonal expansion framework, these problems are expected to be present in all attempts at BBDR modeling.
Immediately following stimulation of differentiation, these cells re-enter the cell cycle and undergo one or two rounds of mitotic clonal expansion for about 24-36 h, after which they permanently withdraw from the cell cycle and terminally differentiate.
8) It has been suggested that EBV infects the primitive pharynx and transforms the epithelial cells, leading to a clonal expansion of these cells.
Marginal-zone B cells in the human lymph node and spleen show somatic hypermutations and display clonal expansion.
a]), indicate that morphological plasticity per se had little or no effect on the rate of clonal expansion in the two homogeneous environments.
coli from different origins suggested that the dissemination of mcr-1 was possibly related to both clonal expansion and horizontal transmission.
Although implementation of BBDR models for low-dose risk estimation have thus far been limited mainly to cancer modeled using a two-stage clonal expansion framework, these problems are expected to be present in all attempts at BBDR modeling.