clofibrate


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clofibrate

 [klo-fi´brāt]
an agent used to reduce elevated serum lipids in treatment of hyperlipoproteinemia, administered orally.

clofibrate

/clo·fi·brate/ (-fi´brāt) an antihyperlipidemic used to reduce serum lipids.

clofibrate

[klō′fəbrāt]
an antihyperlipidemic.
indications It is prescribed in the treatment of high blood levels of triglycerides occurring alone or in combination with high cholesterol levels.
contraindications Liver or kidney dysfunction, pregnancy, lactation, biliary cirrhosis, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse reactions are nausea, diarrhea, weight gain, and a syndrome resembling influenza. This drug interacts with many other drugs and should not be used together with the HMG-CoA reductase inhibitors (statins) used to lower plasma cholesterol levels because this combination has an increased risk for myositis and rhabdomyolysis.

Clofibrate (Altromed-S)

Medication used to lower levels of blood cholesterol and triglycerides.

clofibrate (klōfī´brāt),

n brand names: Abitrate, Atromid-S, Claripex, Novofibrate;
drug class: antihyperlipidemic;
action: inhibits biosyntheis of VLDA and LDL, which are responsible for triglyceride development; increases excretion of neutral steroids;
use: hyperlipidemia types III, IV, V.

clofibrate

an antihyperlipidemic drug.
References in periodicals archive ?
Therefore, our analysis was restricted to rat precursor and potency data for the four compounds Wy-14,643, nafenopin, clofibrate, and DEHP and included both 1-week and 13-week data to separately address transient and sustained changes in DNA synthesis.
Fenofibrate, clofibrate, ciprofibrate, and DEHP, on the other hand, caused a direct dose-dependent depolarization of mitochondrial membrane potential.
Malhotra SC, Ahuja MMS, Sundaram KR (1977) Long term clinical studies on the hypolipidemic effect of Commiphora mukul (guggulu) and clofibrate.
These included the Helsinki Heart Study examining gemfibrozil, (25) the Lipid Research Clinics Coronary Primary Prevention Trial examining cholestyramine, (26) and the World Health Organization clofibrate trial.
chlordiazepoxide, diazepam, chorazepate) Psychotropic drugs * Alcohol * Marijuana * Amphetamines * Barbiturates * Nicotine * Opiates Miscellaneous * Cimetidine * Clofibrate * Digoxin * Estrogens * Indomethacin Figure 3.
Key words: chlorophenoxy herbicides, clofibrate, coronary atherosclerosis, C-reactive protein, diabetes, ischemic heart disease, myocardial infarction.
4] Levels Thyroid-binding globulin: Estrogen exposure, medications (tamoxifen, raloxifene, clofibrate, 5-fluorouracil, perphenazine, methadone), pregnancy, acute liver dis Thyroxine-binding prealbumin: Inherited, pancreatic neuroendocrine tumors Albumin: Familial dysalbuminemic hyperthyroxinemia [T.
Increase in lipoprotein lipase during clofibrate treatment of hypertriglyceridemia in patients on hemodialysis.
associated with the use of other fibrates alone, including clofibrate.
3] Thyroxine-binding globulin Thyroglobulin Thyroid-stimulating immunoglobulins Antithyroglobulin antibodies Antithyroid peroxidase antibodies TABLE 2 Factors and Conditions That Alter Thyroxine Binding Globulin (TBG) Levels Increase TBG Level Decrease TBG Level Congenital Congenital Pregnancy Androgens Oral estrogens Nephrotic syndrome Estrogen-secreting tumors Cirrhosis Acute hepatitis L-asparaginase Primary biliary cirrhosis Glucocorticoids Narcotics (heroin, methadone, hydrocodone) Clofibrate 5-fluorouracil Acute intermittent porphyria TABLE 3.
Use of ZOCOR with fibrate-type drugs such as gemfibrozil or clofibrate should generally be avoided (see WARNINGS, Skeletal Muscle).
Within the ILSI/HESI consortium, the hepatotoxicity working group evaluated the two hepatotoxicants methapyrilene (MP) and clofibrate by gene expression analysis of rat livers (Baker et al.