clofibrate


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clofibrate

 [klo-fi´brāt]
an agent used to reduce elevated serum lipids in treatment of hyperlipoproteinemia, administered orally.

clofibrate

/clo·fi·brate/ (-fi´brāt) an antihyperlipidemic used to reduce serum lipids.

clofibrate

[klō′fəbrāt]
an antihyperlipidemic.
indications It is prescribed in the treatment of high blood levels of triglycerides occurring alone or in combination with high cholesterol levels.
contraindications Liver or kidney dysfunction, pregnancy, lactation, biliary cirrhosis, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse reactions are nausea, diarrhea, weight gain, and a syndrome resembling influenza. This drug interacts with many other drugs and should not be used together with the HMG-CoA reductase inhibitors (statins) used to lower plasma cholesterol levels because this combination has an increased risk for myositis and rhabdomyolysis.

Clofibrate (Altromed-S)

Medication used to lower levels of blood cholesterol and triglycerides.

clofibrate (klōfī´brāt),

n brand names: Abitrate, Atromid-S, Claripex, Novofibrate;
drug class: antihyperlipidemic;
action: inhibits biosyntheis of VLDA and LDL, which are responsible for triglyceride development; increases excretion of neutral steroids;
use: hyperlipidemia types III, IV, V.

clofibrate

an antihyperlipidemic drug.
References in periodicals archive ?
In human studies, guggul has performed impressively, reducing total cholesterol by 11% to 32% and triglycerides by 17% to 30% in three to 12 weeks--comparable or even superior to conventional drugs like clofibrate.
Warfarin, phenylbutazone, and clofibrate increase digoxin levels by competing for protein binding.
ciprofloxacin), erythromycin, metronidazole, sulfonamides (especially TMP/SMX), valproic acid, omeprazole clofibrate, dextrothyroxine, disulfiram Alteration in synthesis of Estrogens (synthetic), clotting factors or degredation androgens (synthetic), ([up arrow] effect) levothyroxine, amiodarone, ampicillin, ethanol, quinidine, influenza vaccine Alteration of hemostatic Heparin process ([up arrow] effect)
Miscellaneous medications: clofibrate, dichlorphenamide, fenfluramine, ketoconazole, methadone, methazolamide, norethindrone, thiabendazole
Lithium and minor tranquillizers such as valium, as well as the use of cimetidine, spironolactone, heparin, clofibrate, disopyramide, estrogens, progestational agents, ketaconazole, and steroids, have also been associated with ED.
Certain drugs may increase the hypoglycemic effect of the sulfonylureas including: androgens, anticoagulants, chloramphenicol, clofibrate, fenfluramine, fluconazole, gemfibrozil, histamine [H.
For instance, a high similarity was observed among the PPARa agonists (fenofibrate, clofibrate and WY-14643), which influence lipid metabolism (Tab.
Prescription drugs include omega-3 fatty acids (Lovaza) and the fibrates gemfibrozil (Lopid) and clofibrate (Atromid-S).
Hepatic peroxisome proliferation: induction by two novel compounds structurally unrelated to clofibrate.
2007), and we find that the chemical structure of osthol is similar to the agonists of PPAR[alpha], clofibrate analogs (Okamoto et al.
Amla also enhances degradation and elimination of cholesterol in animal models, (53) as do drugs such as the fibrates (gemfibrozil, clofibrate, and others).