Reductions of bone mass, structure, and strength in the axial and appendicular skeletons associated with increased bone turnover after ovariectomy in mature cynomolgus monkeys and preventive effects of clodronate
J Bone Miner Res, 17(3): 534-543.
The team of R&D of Abiogen Pharma had developed and continues to develop several bisphosphonates, including ethidronate, alendronate, clodronate
The efficacy of clodronate
, pamidronate, and zoledronate in preventing bone lesions has been investigated in several randomised trials, while for ibandronate limited data from randomised trials are available (32).
Effect of clodronate
on established adjuvant arthritis.
A double-blind, placebo-controlled, randomized trial of oral sodium clodronate
for metastatic prostate cancer (MRC PR05 Trial).
18) compared the effects of 10 mg daily oral aledronate and 100 mg clodronate
(infusion in every 10 days) treatments for two years.
A study evaluated the efficacy of intravenous clodronate
in patients with reflex sympathetic dystrophy syndrome.
Interestingly, removal of these macrophages using the specific macrophage toxic agent clodronate
ameliorates many aspects of the TGF-[beta]1 phenotype, including collagen accumulation (E.
However, results from another prior study on the impact of clodronate
on fracture risk suggested that osteoporotic women with the highest baseline fracture risk stood to gain the most from bisphosphonate treatment (Osteoporosis Int.
Two small studies, in which either postmenopausal women with breast cancer received oral clodronate
or premenopausal women with chemotherapy induced menopause received oral risedronate, showed increases in BMD, after 2 years of bisphosphonate treatment, of between 2.
The research study, jointly led by Prof Malcolm Mason, at Cardiff University, and Prof David Dearnaley, of the Institute of Cancer Research, examined the long-term effect of sodium clodronate
on men with prostate cancer.
The research study, jointly led by Prof Malcolm Mason at Cardiff University and Prof David Dearnaley of the Institute of Cancer Research, examined the long-term effect of sodium clodronate
on men with advanced and localised prostate cancer.