clock

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clock

(klok) a device for measuring time.
biological clock  the physiologic mechanism which governs the rhythmic occurrence of certain biochemical, physiologic, and behavioral phenomena in living organisms.

clock

(klŏk)
n.
1. An instrument other than a watch for measuring or indicating time, especially a mechanical or electronic device having a numbered dial and moving hands or a digital display.
2. A biological clock.
v. clocked, clocking, clocks
v.tr.
To register or record with a mechanical device: clocked the winds at 60 miles per hour.

clock′er n.

CLOCK

A gene on chromosome 4q12 that encodes a ubiquitously expressed human homolog of the mouse clock gene, which forms a heterodimer with ARNTL and activates E-box element transcription of several circadian clock proteins (e.g., PER1 and PER2). CLOCK is highly expressed in the suprachiasmatic nucleus.

Molecular pathology
CLOCK-ARNTL double mutations in the PAS domains result in syngernistic desensitisation to high levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1, disrupting circadian rhythmicity.

clock

(klok)
A device for measuring time.

biological clock

1. An internal system in organisms that influences behavior in a rhythmic manner. Functions such as growth, feeding, secretion of hormones, the rate of drug action, the wake-sleep cycle, the menstrual cycle, and reproduction coincide with certain external events such as day and night, the tides, and the seasons. Biological clocks appear to be set by environmental conditions in some animals, but if these animals are isolated from their environment they continue to function according to the usual rhythm. A gradual change in environment does produce a gradual change in the timing of the biological clock. See: circadian; maladaptation to night work; zeitgeber
2. A colloquial term for the decrease in fertility that accompanies aging, particularly as women approach the age of 35.

Patient discussion about clock

Q. How do you wake up in the morning if your narcolepsy is so severe you can't hear the alarm clock, phone ring? biggest problem is sleep paralysis, can't wake up. Late for work, everything, life is suffering because of severity. Have tried ritalin, natural supplements, hypnosis therapy, Provigal, antidepressants, nothing seems to work. Employer thinks it's an excuse, friends are irritated, I'm at my wits end. Life is spent sleeping more than awake.

A. Narcolepsy cannot yet be cured. But EDS and cataplexy, the most disabling symptoms of the disorder, can be controlled in most patients with drug treatment. Often the treatment regimen is modified as symptoms change. For decades, doctors have used central nervous system stimulants-amphetamines such as methylphenidate, dextroamphetamine, methamphetamine, and pemoline-to alleviate EDS and reduce the incidence of sleep attacks. For most patients these medications are generally quite effective at reducing daytime drowsiness and improving levels of alertness. However, they are associated with a wide array of undesirable side effects so their use must be carefully monitored. Common side effects include irritability and nervousness, shakiness, disturbances in heart rhythm, stomach upset, nighttime sleep disruption, and anorexia. For full article: http://www.ninds.nih.gov/disorders/narcolepsy/detail_narcolepsy.htm#120393201 Hope this helps.

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References in periodicals archive ?
Better to untangle the cable and crank clockwise to wind it back onto the drum.
This agreement validates the appeal of Win3D as a fresh and exciting platform for telecom companies providing Internet services," said Nir Ronen, CEO of ClockWise Technologies.
In clockwise rotation, the flagella come apart and the bacterium tumbles head over heel, reorienting its swimming direction (SN:5/12/84, p.
Then on Page 3-21 it shows the rotation as right; side clockwise and left; side counterclockwise.
Clockwise, from top left: Bobbi Brown lip palette, pounds 26 @ Frasers; wish candle, with proceeds to breast cancer research, pounds 6 @ Warehouse; Oil of Evening Primrose jug gift set, with body lotion, shower cream and a facecloth, pounds 10 @ Boots; Nails Inc Perfect Paws gift pack, pounds 30, Nails Inc @ Frasers; Chanel No5, Eau de toilette spray, 50ml, pounds 34.
THE Monaco grand prix is run in a clockwise direction, not anti-clockwise as in the graphic on Page 52, Saturday.
ClockWise provides traditional zero skew as well as innovative useful skew clock tree synthesis that is plug-and-play with popular place and route tools.
Researchers can switch the electrons' direction of polarization back and forth between clockwise and anticlockwise by changing the polarization of the laser light.
2) The cast of ``That '70s Show'' - clockwise from left, Ashton Kutcher, Danny Masterson, Mila Kunis, Wilmer Valderrama, Laura Prepon and Topher Grace- boogies on in tonight's season finale.
CLOCKWISE FROM TOP LEFT: Pink floral head dress, pounds 15, M&S; Shiny bobbles, pounds 2 per pack, M&S; Aqua floral band, pounds 3.